Dark-field confocal photoacoustic microscopy

Hao F Zhang, Konstantin Maslov, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Photoacoustic microscopy (PAM) [1-3] is a recently developed modality of photoacoustic (PA) imaging. Similar to other PA imaging technologies, PAM detects laser-induced ultrasonic waves (referred to as PA waves) to image the internal distribution of optical energy deposition (specific optical absorption) in biological tissue. Therefore, PAM reveals physiologically specific optical absorption contrast. However, it differs from reconstruction-based photoacoustic tomography (PAT) [4-7] in several aspects. First, PAM provides high spatial resolution by detecting the high-frequency components of the PA waves [8]. Second, PAM optimizes for the signal-to-noise ratio (SNR) by employing an optical-ultrasonic confocal geometry [2]. Third, PAM involves no inverse reconstruction algorithms [9,10]. Fourth, PAM minimizes unwanted interferences by employing novel optical illumination design.

Original languageEnglish (US)
Title of host publicationPhotoacoustic Imaging and Spectroscopy
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781420059922
ISBN (Print)9781420059915
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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