DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

A. A. Fienberg; N. Hiroi; P. G. Mermelstein; W. J. Song; G. L. Snyder; A. Nishi; A. Cheramy; J. P. O'Callaghan; D. B. Miller; D. G. Cole; R. Corbett; C. N. Haile; D. C. Cooper; S. P. Onn; A. A. Grace; C. C. Ouimet; F. J. White; S. E. Hyman; D. J. Surmeier; J. A. Girault; E. J. Nestler; P. Greengard

doi:10.1126/science.281.5378.838

DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

A. A. Fienberg^*, N. Hiroi, P. G. Mermelstein, W. J. Song, G. L. Snyder, A. Nishi, A. Cheramy, J. P. O'Callaghan, D. B. Miller, D. G. Cole, R. Corbett, C. N. Haile, D. C. Cooper, S. P. Onn, A. A. Grace, C. C. Ouimet, F. J. White, S. E. Hyman, D. J. Surmeier, J. A. GiraultE. J. Nestler, P. Greengard

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

398 Scopus citations

Abstract

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

Original language	English (US)
Pages (from-to)	838-842
Number of pages	5
Journal	Science
Volume	281
Issue number	5378
DOIs	https://doi.org/10.1126/science.281.5378.838
State	Published - Aug 7 1998

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Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W. J., Snyder, G. L., Nishi, A., Cheramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., Corbett, R., Haile, C. N., Cooper, D. C., Onn, S. P., Grace, A. A., Ouimet, C. C., White, F. J., Hyman, S. E., Surmeier, D. J., ... Greengard, P. (1998). DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science, 281(5378), 838-842. https://doi.org/10.1126/science.281.5378.838

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title = "DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission",

abstract = "Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.",

author = "Fienberg, {A. A.} and N. Hiroi and Mermelstein, {P. G.} and Song, {W. J.} and Snyder, {G. L.} and A. Nishi and A. Cheramy and O'Callaghan, {J. P.} and Miller, {D. B.} and Cole, {D. G.} and R. Corbett and Haile, {C. N.} and Cooper, {D. C.} and Onn, {S. P.} and Grace, {A. A.} and Ouimet, {C. C.} and White, {F. J.} and Hyman, {S. E.} and Surmeier, {D. J.} and Girault, {J. A.} and Nestler, {E. J.} and P. Greengard",

year = "1998",

month = aug,

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doi = "10.1126/science.281.5378.838",

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Fienberg, AA, Hiroi, N, Mermelstein, PG, Song, WJ, Snyder, GL, Nishi, A, Cheramy, A, O'Callaghan, JP, Miller, DB, Cole, DG, Corbett, R, Haile, CN, Cooper, DC, Onn, SP, Grace, AA, Ouimet, CC, White, FJ, Hyman, SE, Surmeier, DJ, Girault, JA, Nestler, EJ & Greengard, P 1998, 'DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission', Science, vol. 281, no. 5378, pp. 838-842. https://doi.org/10.1126/science.281.5378.838

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T2 - Regulator of the efficacy of dopaminergic neurotransmission

AU - Fienberg, A. A.

AU - Hiroi, N.

AU - Mermelstein, P. G.

AU - Song, W. J.

AU - Snyder, G. L.

AU - Nishi, A.

AU - Cheramy, A.

AU - O'Callaghan, J. P.

AU - Miller, D. B.

AU - Cole, D. G.

AU - Corbett, R.

AU - Haile, C. N.

AU - Cooper, D. C.

AU - Onn, S. P.

AU - Grace, A. A.

AU - Ouimet, C. C.

AU - White, F. J.

AU - Hyman, S. E.

AU - Surmeier, D. J.

AU - Girault, J. A.

AU - Nestler, E. J.

AU - Greengard, P.

PY - 1998/8/7

Y1 - 1998/8/7

N2 - Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

AB - Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

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DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

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