Modern tire compound design is confronted with the simultaneous optimization of multiple performance properties, most of which have tradeoffs between the properties. In order to uncover new design principles to overcome these historical tradeoffs, multiscale compound experiment, physics, and simulation are being developed and integrated into next-generation design platforms across the tire industry. This chapter describes the efforts in our laboratories to quantify compound structures and properties at multiple scales—from nanometers to microns—and their application in compound simulations. This integration of experiment and simulation has been found to be critical to highlighting the levers in data-driven multiscale compound design. We also provide a glimpse into the next set of capabilities, particularly from data science, which will impact future compound design.