Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies

Zhenya Tang*, Guilin Tang, Shimin Hu, Keyur P. Patel, C. Cameron Yin, Wei Wang, Pei Lin, Gokce A. Toruner, Chi Y. Ok, Jun Gu, Xinyan Lu, Joseph D. Khoury, L. Jeffrey Medeiros

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Data in this article presents the results of conventional cytogenetics and fluorescence in situ hybridization (FISH) analyses in 129 patients with confirmed MECOM rearrangement ( [1]. Generally, the MECOM rearrangement has arisen through translocation, inversion, and insertion and/or unknown mechanism. In addition to the typical chromosomal aberrations, inv(3)(q21q26.2) and t(3; 3)(q21; q26.6) [2–4], over 50% of cases presented here exhibit a wide spectrum of MECOM rearrangement-driven, atypical chromosomal aberrations, including inv(3) with breakpoint other than 3q21; t(1; 3); t(2; 3); t(3; 6); t(3; 8); t(3; 12); t(3; 17); t(3; 21) as well as an insertion of 3q26.2 into different chromosomes. These cases are thoroughly characterized by karyotyping, interphase-, metaphase-, map-back FISH and whole chromosomal painting (WCP) analyses.

Original languageEnglish (US)
Article number104025
JournalData in Brief
StatePublished - Jun 2019


  • Fluorescence in situ hybridization (FISH)
  • Insertion
  • Inversion
  • MECOM rearrangement
  • Translocation

ASJC Scopus subject areas

  • General

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