@article{4894d67bc7e1428fa98c8ea1877ac2c8,
title = "Death Induced by CD95 or CD95 Ligand Elimination",
abstract = "CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL expression, and preferentially affects cancer cells. All tumors that formed in mouse models of low-grade serous ovarian cancer or chemically induced liver cancer with tissue-specific deletion of CD95 still expressed CD95, suggesting that cancer cannot form in the absence of CD95. Death induced by CD95R/L elimination (DICE) is characterized by an increase incell size, production of mitochondrial ROS, and DNA damage. It resembles a necrotic form of mitotic catastrophe. No single drug was found to completely block this form of cell death, and it could also not be blocked by the knockdown of a single gene, making it a promising way to kill cancer cells.",
author = "Abbas Hadji and Paolo Ceppi and Murmann, {Andrea E.} and Sonia Brockway and Abhinandan Pattanayak and Bhavneet Bhinder and Annika Hau and {De Chant}, Shirley and Vamsi Parimi and Piotre Kolesza and Richards, {Jo Anne} and Navdeep Chandel and Hakim Djaballah and Peter, {Marcus E.}",
note = "Funding Information: We are grateful to Drs. E. Lengyel and A. Mitra for providing primary omental fibroblasts. We would like to thank Drs. B. Vogelstein for providing the HCT116 TP53 −/− and HCT116 DICER −/− cells, T. Li for performing the tissue stainings for CD95, and Sam Bettis for performing the small molecule screen. We would also like to thank Drs. J. Lahti, J. Rossi, and Zhen-Gang Liu for providing the NB7 cells, the Tet-inducible vector, and the MLKL knockdown cells, respectively. We thank Dr. J. Licht for help in performing comet assays. The HTS Core Facility is supported by Mr. William H. Goodwin and Mrs. Alice Goodwin, the Commonwealth Foundation for Cancer Research, the ETC of MSKCC, the Lillian S. Wells Foundation, and by a NIH/NCI Cancer Center Support Grant 5 P30 CA008748-44. S.B. is supported in part by NIH/NCI training grant T32CA09560. This work was funded by the NCI (RO1 CA112240 to M.E.P.). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "2014",
month = oct,
day = "4",
doi = "10.1016/j.celrep.2014.02.035",
language = "English (US)",
volume = "7",
pages = "208--222",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}