TY - JOUR
T1 - Deceased donors with multidrug-resistant organisms
T2 - Implications and future directions
AU - Pouch, Stephanie M.
AU - Ison, Michael G.
N1 - Publisher Copyright:
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Purpose of reviewOrgan utilization from donors infected or colonized with multidrug-resistant organisms (MDROs) remains inconsistent, and hesitancy to accept organs from these donors may relate to poor outcomes among solid organ transplant recipients with MDRO donor-derived infections (DDIs). An improved understanding of the risk factors for donor MDRO colonization or infection and the risk of MDRO DDI is needed to safely expand the donor pool while minimizing unnecessary organ discard.Recent findingsRecent studies have begun to delineate risk factors for MDRO acquisition among deceased donors and the epidemiology of MDRO DDIs, but additional efforts are warranted to inform optimal approaches to donor evaluation, risk stratification, management, interfacility and interagency data sharing, and approaches to recipient management.SummaryThis review summaries recent data regarding risk factors for MDRO colonization and infection in deceased donors, epidemiology of MDRO DDIs, and current approaches to donors harboring MDROs and provides a framework for future research and collaboration.
AB - Purpose of reviewOrgan utilization from donors infected or colonized with multidrug-resistant organisms (MDROs) remains inconsistent, and hesitancy to accept organs from these donors may relate to poor outcomes among solid organ transplant recipients with MDRO donor-derived infections (DDIs). An improved understanding of the risk factors for donor MDRO colonization or infection and the risk of MDRO DDI is needed to safely expand the donor pool while minimizing unnecessary organ discard.Recent findingsRecent studies have begun to delineate risk factors for MDRO acquisition among deceased donors and the epidemiology of MDRO DDIs, but additional efforts are warranted to inform optimal approaches to donor evaluation, risk stratification, management, interfacility and interagency data sharing, and approaches to recipient management.SummaryThis review summaries recent data regarding risk factors for MDRO colonization and infection in deceased donors, epidemiology of MDRO DDIs, and current approaches to donors harboring MDROs and provides a framework for future research and collaboration.
KW - donor-derived infection
KW - multidrug-resistant organism
KW - solid organ transplantation
UR - http://www.scopus.com/inward/record.url?scp=85141509176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85141509176&partnerID=8YFLogxK
U2 - 10.1097/MOT.0000000000000991
DO - 10.1097/MOT.0000000000000991
M3 - Review article
C2 - 36354250
AN - SCOPUS:85141509176
SN - 1087-2418
VL - 27
SP - 250
EP - 256
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
IS - 4
ER -