Deceased donors with multidrug-resistant organisms: Implications and future directions

Stephanie M. Pouch, Michael G. Ison

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Purpose of reviewOrgan utilization from donors infected or colonized with multidrug-resistant organisms (MDROs) remains inconsistent, and hesitancy to accept organs from these donors may relate to poor outcomes among solid organ transplant recipients with MDRO donor-derived infections (DDIs). An improved understanding of the risk factors for donor MDRO colonization or infection and the risk of MDRO DDI is needed to safely expand the donor pool while minimizing unnecessary organ discard.Recent findingsRecent studies have begun to delineate risk factors for MDRO acquisition among deceased donors and the epidemiology of MDRO DDIs, but additional efforts are warranted to inform optimal approaches to donor evaluation, risk stratification, management, interfacility and interagency data sharing, and approaches to recipient management.SummaryThis review summaries recent data regarding risk factors for MDRO colonization and infection in deceased donors, epidemiology of MDRO DDIs, and current approaches to donors harboring MDROs and provides a framework for future research and collaboration.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalCurrent opinion in organ transplantation
Volume27
Issue number4
DOIs
StatePublished - Aug 1 2022

Keywords

  • donor-derived infection
  • multidrug-resistant organism
  • solid organ transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy

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