Abstract
Proteins can be modified by post-translational modifications such as phosphorylation, methylation, acetylation and ubiquitylation, creating binding sites for specific protein domains. Methylation has pivotal roles in the formation of complexes that are involved in cellular regulation, including in the generation of small RNAs. Arginine methylation was discovered half a century ago, but the ability of methylarginine sites to serve as binding motifs for members of the Tudor protein family, and the functional significance of the protein-protein interactions that are mediated by Tudor domains, has only recently been appreciated. Tudor proteins are now known to be present in PIWI complexes, where they are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA (piRNA) pathway in the germ line.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 629-642 |
| Number of pages | 14 |
| Journal | Nature Reviews Molecular Cell Biology |
| Volume | 12 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2011 |
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
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Deciphering arginine methylation : Tudor tells the tale. / Chen, Chen; Nott, Timothy J.; Jin, Jing; Pawson, Tony.
In: Nature Reviews Molecular Cell Biology, Vol. 12, No. 10, 01.10.2011, p. 629-642.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Deciphering arginine methylation
T2 - Tudor tells the tale
AU - Chen, Chen
AU - Nott, Timothy J.
AU - Jin, Jing
AU - Pawson, Tony
PY - 2011/10/1
Y1 - 2011/10/1
N2 - Proteins can be modified by post-translational modifications such as phosphorylation, methylation, acetylation and ubiquitylation, creating binding sites for specific protein domains. Methylation has pivotal roles in the formation of complexes that are involved in cellular regulation, including in the generation of small RNAs. Arginine methylation was discovered half a century ago, but the ability of methylarginine sites to serve as binding motifs for members of the Tudor protein family, and the functional significance of the protein-protein interactions that are mediated by Tudor domains, has only recently been appreciated. Tudor proteins are now known to be present in PIWI complexes, where they are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA (piRNA) pathway in the germ line.
AB - Proteins can be modified by post-translational modifications such as phosphorylation, methylation, acetylation and ubiquitylation, creating binding sites for specific protein domains. Methylation has pivotal roles in the formation of complexes that are involved in cellular regulation, including in the generation of small RNAs. Arginine methylation was discovered half a century ago, but the ability of methylarginine sites to serve as binding motifs for members of the Tudor protein family, and the functional significance of the protein-protein interactions that are mediated by Tudor domains, has only recently been appreciated. Tudor proteins are now known to be present in PIWI complexes, where they are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA (piRNA) pathway in the germ line.
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UR - http://www.scopus.com/inward/citedby.url?scp=80053132089&partnerID=8YFLogxK
U2 - 10.1038/nrm3185
DO - 10.1038/nrm3185
M3 - Review article
VL - 12
SP - 629
EP - 642
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
SN - 1471-0072
IS - 10
ER -