Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin

Sourav Chandra, Nina L. Suresh, Babak Afsharipour, William Zev Rymer, Aleš Holobar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High-density surface electromyography(HDsEMG) decomposition has allowed us to study individual motor unit (MU) responses in great detail during voluntary or reflex muscle contraction. Being noninvasive in nature, the technique has been widely used for many different applications in both healthy and stroke impaired populations. Here for the first time, we demonstrate the use of a HDsEMG based MU decomposition technique to study the morphological changes in the recruited MU population after botulinum toxin (BT) injection in the biceps brachii muscle for spasticity management in chronic hemiparetic stroke survivors. Three stroke survivors were examined before and after intramuscular (biceps brachii) BT injections. The HDsEMG grid enabled simultaneous recordings over the entire muscle. We have recorded both force and the surface electromyogram (sEMG) during voluntary isometric contraction tasks. The HDsEMG was decomposed using the convolution kernel compensation (CKC) method. We report a 60% increase of the peak to peak amplitude of the motor unit action potential (MUAP) signals after the BT injection compared to pre-injection values. The overall generated muscle force and sEMG values decreased during this period compared to their pre-injection level. We discuss potential mechanisms that would result in the emergence of larger MUAPs in the weeks immediately following intramuscular BT.

Original languageEnglish (US)
Title of host publication8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020
EditorsTomaz Jarm, Aleksandra Cvetkoska, Samo Mahnič-Kalamiza, Damijan Miklavcic
PublisherSpringer Science and Business Media Deutschland GmbH
Pages333-340
Number of pages8
ISBN (Print)9783030646097
DOIs
StatePublished - 2021
Event8th European Medical and Biological Engineering Conference, EMBEC 2020 - Portorož, Slovenia
Duration: Nov 29 2020Dec 3 2020

Publication series

NameIFMBE Proceedings
Volume80
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

Conference8th European Medical and Biological Engineering Conference, EMBEC 2020
CountrySlovenia
CityPortorož
Period11/29/2012/3/20

Keywords

  • Botulinum toxin
  • HDsEMG
  • Motor unit action potential
  • Spasticity

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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