Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin

Sourav Chandra; Nina L. Suresh; Babak Afsharipour; William Zev Rymer; Aleš Holobar

doi:10.1007/978-3-030-64610-3_39

Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin

Sourav Chandra, Nina L. Suresh, Babak Afsharipour, William Zev Rymer, Aleš Holobar^*

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

High-density surface electromyography(HDsEMG) decomposition has allowed us to study individual motor unit (MU) responses in great detail during voluntary or reflex muscle contraction. Being noninvasive in nature, the technique has been widely used for many different applications in both healthy and stroke impaired populations. Here for the first time, we demonstrate the use of a HDsEMG based MU decomposition technique to study the morphological changes in the recruited MU population after botulinum toxin (BT) injection in the biceps brachii muscle for spasticity management in chronic hemiparetic stroke survivors. Three stroke survivors were examined before and after intramuscular (biceps brachii) BT injections. The HDsEMG grid enabled simultaneous recordings over the entire muscle. We have recorded both force and the surface electromyogram (sEMG) during voluntary isometric contraction tasks. The HDsEMG was decomposed using the convolution kernel compensation (CKC) method. We report a 60% increase of the peak to peak amplitude of the motor unit action potential (MUAP) signals after the BT injection compared to pre-injection values. The overall generated muscle force and sEMG values decreased during this period compared to their pre-injection level. We discuss potential mechanisms that would result in the emergence of larger MUAPs in the weeks immediately following intramuscular BT.

Original language	English (US)
Title of host publication	8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020
Editors	Tomaz Jarm, Aleksandra Cvetkoska, Samo Mahnič-Kalamiza, Damijan Miklavcic
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	333-340
Number of pages	8
ISBN (Print)	9783030646097
DOIs	https://doi.org/10.1007/978-3-030-64610-3_39
State	Published - 2021
Event	8th European Medical and Biological Engineering Conference, EMBEC 2020 - Portorož, Slovenia Duration: Nov 29 2020 → Dec 3 2020

Publication series

Name	IFMBE Proceedings
Volume	80
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Conference

Conference	8th European Medical and Biological Engineering Conference, EMBEC 2020
Country/Territory	Slovenia
City	Portorož
Period	11/29/20 → 12/3/20

Funding

Acknowledgment. This study was supported by the Slovenian Research Agency (projects BI-US/18-19-037, J2-7357, J2-1731 and Programme funding P2-0041) and by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) through Advanced Rehabilitation Research and Training (ARRT) and Rehabilitation Engineering Research Center (RERC) program at Northwestern University Chicago USA.

Keywords

Botulinum toxin
HDsEMG
Motor unit action potential
Spasticity

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-64610-3_39

Cite this

Chandra, S., Suresh, N. L., Afsharipour, B., Rymer, W. Z., & Holobar, A. (2021). Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin. In T. Jarm, A. Cvetkoska, S. Mahnič-Kalamiza, & D. Miklavcic (Eds.), 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020 (pp. 333-340). (IFMBE Proceedings; Vol. 80). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-64610-3_39

Chandra, Sourav ; Suresh, Nina L. ; Afsharipour, Babak et al. / Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin. 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. editor / Tomaz Jarm ; Aleksandra Cvetkoska ; Samo Mahnič-Kalamiza ; Damijan Miklavcic. Springer Science and Business Media Deutschland GmbH, 2021. pp. 333-340 (IFMBE Proceedings).

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title = "Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin",

abstract = "High-density surface electromyography(HDsEMG) decomposition has allowed us to study individual motor unit (MU) responses in great detail during voluntary or reflex muscle contraction. Being noninvasive in nature, the technique has been widely used for many different applications in both healthy and stroke impaired populations. Here for the first time, we demonstrate the use of a HDsEMG based MU decomposition technique to study the morphological changes in the recruited MU population after botulinum toxin (BT) injection in the biceps brachii muscle for spasticity management in chronic hemiparetic stroke survivors. Three stroke survivors were examined before and after intramuscular (biceps brachii) BT injections. The HDsEMG grid enabled simultaneous recordings over the entire muscle. We have recorded both force and the surface electromyogram (sEMG) during voluntary isometric contraction tasks. The HDsEMG was decomposed using the convolution kernel compensation (CKC) method. We report a 60% increase of the peak to peak amplitude of the motor unit action potential (MUAP) signals after the BT injection compared to pre-injection values. The overall generated muscle force and sEMG values decreased during this period compared to their pre-injection level. We discuss potential mechanisms that would result in the emergence of larger MUAPs in the weeks immediately following intramuscular BT.",

keywords = "Botulinum toxin, HDsEMG, Motor unit action potential, Spasticity",

author = "Sourav Chandra and Suresh, {Nina L.} and Babak Afsharipour and Rymer, {William Zev} and Ale{\v s} Holobar",

note = "Funding Information: Acknowledgment. This study was supported by the Slovenian Research Agency (projects BI-US/18-19-037, J2-7357, J2-1731 and Programme funding P2-0041) and by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) through Advanced Rehabilitation Research and Training (ARRT) and Rehabilitation Engineering Research Center (RERC) program at Northwestern University Chicago USA. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.; 8th European Medical and Biological Engineering Conference, EMBEC 2020 ; Conference date: 29-11-2020 Through 03-12-2020",

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isbn = "9783030646097",

series = "IFMBE Proceedings",

publisher = "Springer Science and Business Media Deutschland GmbH",

pages = "333--340",

editor = "Tomaz Jarm and Aleksandra Cvetkoska and Samo Mahni{\v c}-Kalamiza and Damijan Miklavcic",

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Chandra, S, Suresh, NL, Afsharipour, B, Rymer, WZ & Holobar, A 2021, Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin. in T Jarm, A Cvetkoska, S Mahnič-Kalamiza & D Miklavcic (eds), 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. IFMBE Proceedings, vol. 80, Springer Science and Business Media Deutschland GmbH, pp. 333-340, 8th European Medical and Biological Engineering Conference, EMBEC 2020, Portorož, Slovenia, 11/29/20. https://doi.org/10.1007/978-3-030-64610-3_39

Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin. / Chandra, Sourav; Suresh, Nina L.; Afsharipour, Babak et al.
8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. ed. / Tomaz Jarm; Aleksandra Cvetkoska; Samo Mahnič-Kalamiza; Damijan Miklavcic. Springer Science and Business Media Deutschland GmbH, 2021. p. 333-340 (IFMBE Proceedings; Vol. 80).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Suresh, Nina L.

AU - Afsharipour, Babak

AU - Rymer, William Zev

AU - Holobar, Aleš

N1 - Funding Information: Acknowledgment. This study was supported by the Slovenian Research Agency (projects BI-US/18-19-037, J2-7357, J2-1731 and Programme funding P2-0041) and by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) through Advanced Rehabilitation Research and Training (ARRT) and Rehabilitation Engineering Research Center (RERC) program at Northwestern University Chicago USA. Publisher Copyright: © 2021, Springer Nature Switzerland AG.

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N2 - High-density surface electromyography(HDsEMG) decomposition has allowed us to study individual motor unit (MU) responses in great detail during voluntary or reflex muscle contraction. Being noninvasive in nature, the technique has been widely used for many different applications in both healthy and stroke impaired populations. Here for the first time, we demonstrate the use of a HDsEMG based MU decomposition technique to study the morphological changes in the recruited MU population after botulinum toxin (BT) injection in the biceps brachii muscle for spasticity management in chronic hemiparetic stroke survivors. Three stroke survivors were examined before and after intramuscular (biceps brachii) BT injections. The HDsEMG grid enabled simultaneous recordings over the entire muscle. We have recorded both force and the surface electromyogram (sEMG) during voluntary isometric contraction tasks. The HDsEMG was decomposed using the convolution kernel compensation (CKC) method. We report a 60% increase of the peak to peak amplitude of the motor unit action potential (MUAP) signals after the BT injection compared to pre-injection values. The overall generated muscle force and sEMG values decreased during this period compared to their pre-injection level. We discuss potential mechanisms that would result in the emergence of larger MUAPs in the weeks immediately following intramuscular BT.

AB - High-density surface electromyography(HDsEMG) decomposition has allowed us to study individual motor unit (MU) responses in great detail during voluntary or reflex muscle contraction. Being noninvasive in nature, the technique has been widely used for many different applications in both healthy and stroke impaired populations. Here for the first time, we demonstrate the use of a HDsEMG based MU decomposition technique to study the morphological changes in the recruited MU population after botulinum toxin (BT) injection in the biceps brachii muscle for spasticity management in chronic hemiparetic stroke survivors. Three stroke survivors were examined before and after intramuscular (biceps brachii) BT injections. The HDsEMG grid enabled simultaneous recordings over the entire muscle. We have recorded both force and the surface electromyogram (sEMG) during voluntary isometric contraction tasks. The HDsEMG was decomposed using the convolution kernel compensation (CKC) method. We report a 60% increase of the peak to peak amplitude of the motor unit action potential (MUAP) signals after the BT injection compared to pre-injection values. The overall generated muscle force and sEMG values decreased during this period compared to their pre-injection level. We discuss potential mechanisms that would result in the emergence of larger MUAPs in the weeks immediately following intramuscular BT.

KW - Botulinum toxin

KW - HDsEMG

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KW - Spasticity

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A2 - Jarm, Tomaz

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PB - Springer Science and Business Media Deutschland GmbH

T2 - 8th European Medical and Biological Engineering Conference, EMBEC 2020

Y2 - 29 November 2020 through 3 December 2020

ER -

Chandra S, Suresh NL, Afsharipour B, Rymer WZ, Holobar A. Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin. In Jarm T, Cvetkoska A, Mahnič-Kalamiza S, Miklavcic D, editors, 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. Springer Science and Business Media Deutschland GmbH. 2021. p. 333-340. (IFMBE Proceedings). doi: 10.1007/978-3-030-64610-3_39

Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin

Abstract

Publication series

Conference

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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