@inproceedings{c2ee1e9dc15a4463bdfd31064ccaafe0,
title = "Decomposition of High Density Electromyogram Reveals Changes in Motor Unit Action Potential Amplitude After Intramuscular Botulinum Toxin",
abstract = "High-density surface electromyography(HDsEMG) decomposition has allowed us to study individual motor unit (MU) responses in great detail during voluntary or reflex muscle contraction. Being noninvasive in nature, the technique has been widely used for many different applications in both healthy and stroke impaired populations. Here for the first time, we demonstrate the use of a HDsEMG based MU decomposition technique to study the morphological changes in the recruited MU population after botulinum toxin (BT) injection in the biceps brachii muscle for spasticity management in chronic hemiparetic stroke survivors. Three stroke survivors were examined before and after intramuscular (biceps brachii) BT injections. The HDsEMG grid enabled simultaneous recordings over the entire muscle. We have recorded both force and the surface electromyogram (sEMG) during voluntary isometric contraction tasks. The HDsEMG was decomposed using the convolution kernel compensation (CKC) method. We report a 60% increase of the peak to peak amplitude of the motor unit action potential (MUAP) signals after the BT injection compared to pre-injection values. The overall generated muscle force and sEMG values decreased during this period compared to their pre-injection level. We discuss potential mechanisms that would result in the emergence of larger MUAPs in the weeks immediately following intramuscular BT.",
keywords = "Botulinum toxin, HDsEMG, Motor unit action potential, Spasticity",
author = "Sourav Chandra and Suresh, {Nina L.} and Babak Afsharipour and Rymer, {William Zev} and Ale{\v s} Holobar",
note = "Funding Information: Acknowledgment. This study was supported by the Slovenian Research Agency (projects BI-US/18-19-037, J2-7357, J2-1731 and Programme funding P2-0041) and by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) through Advanced Rehabilitation Research and Training (ARRT) and Rehabilitation Engineering Research Center (RERC) program at Northwestern University Chicago USA. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.; 8th European Medical and Biological Engineering Conference, EMBEC 2020 ; Conference date: 29-11-2020 Through 03-12-2020",
year = "2021",
doi = "10.1007/978-3-030-64610-3_39",
language = "English (US)",
isbn = "9783030646097",
series = "IFMBE Proceedings",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "333--340",
editor = "Tomaz Jarm and Aleksandra Cvetkoska and Samo Mahni{\v c}-Kalamiza and Damijan Miklavcic",
booktitle = "8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020",
address = "Germany",
}