Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists

Ashty Stephen Karim; Dylan M. Brown; Chloé M. Archuleta; Sharisse Grannan; Ludmilla Aristilde; Yogesh Goyal; Joshua N Leonard; Niall M. Mangan; Arthur Prindle; Gabriel J. Rocklin; Keith J. Tyo; Laurie S Zoloth; Michael Christopher Jewett; Susanna C Calkins; Neha P. Kamat; Danielle Tullman-Ercek; Julius B. Lucks

doi:10.1038/s41467-024-49626-x

Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists

Ashty Stephen Karim^*, Dylan M. Brown, Chloé M. Archuleta, Sharisse Grannan, Ludmilla Aristilde, Yogesh Goyal, Joshua N Leonard, Niall M. Mangan, Arthur Prindle, Gabriel J. Rocklin, Keith J. Tyo, Laurie S Zoloth, Michael Christopher Jewett, Susanna C Calkins, Neha P. Kamat, Danielle Tullman-Ercek, Julius B. Lucks^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Synthetic biology allows us to reuse, repurpose, and reconfigure biological systems to address society’s most pressing challenges. Developing biotechnologies in this way requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. We created a framework for synthetic biology training that deconstructs biotechnologies across scales—molecular, circuit/network, cell/cell-free systems, biological communities, and societal—giving students a holistic toolkit to integrate cross-disciplinary concepts towards responsible innovation of successful biotechnologies. We present this framework, lessons learned, and inclusive teaching materials to allow its adaption to train the next generation of synthetic biologists.

Original language	English (US)
Article number	5425
Journal	Nature communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-49626-x
State	Published - Dec 2024

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Karim, A. S., Brown, D. M., Archuleta, C. M., Grannan, S., Aristilde, L., Goyal, Y., Leonard, J. N., Mangan, N. M., Prindle, A., Rocklin, G. J., Tyo, K. J., Zoloth, L. S., Jewett, M. C., Calkins, S. C., Kamat, N. P., Tullman-Ercek, D., & Lucks, J. B. (2024). Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists. Nature communications, 15(1), Article 5425. https://doi.org/10.1038/s41467-024-49626-x

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abstract = "Synthetic biology allows us to reuse, repurpose, and reconfigure biological systems to address society{\textquoteright}s most pressing challenges. Developing biotechnologies in this way requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. We created a framework for synthetic biology training that deconstructs biotechnologies across scales—molecular, circuit/network, cell/cell-free systems, biological communities, and societal—giving students a holistic toolkit to integrate cross-disciplinary concepts towards responsible innovation of successful biotechnologies. We present this framework, lessons learned, and inclusive teaching materials to allow its adaption to train the next generation of synthetic biologists.",

author = "Karim, {Ashty Stephen} and Brown, {Dylan M.} and Archuleta, {Chlo{\'e} M.} and Sharisse Grannan and Ludmilla Aristilde and Yogesh Goyal and Leonard, {Joshua N} and Mangan, {Niall M.} and Arthur Prindle and Rocklin, {Gabriel J.} and Tyo, {Keith J.} and Zoloth, {Laurie S} and Jewett, {Michael Christopher} and Calkins, {Susanna C} and Kamat, {Neha P.} and Danielle Tullman-Ercek and Lucks, {Julius B.}",

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doi = "10.1038/s41467-024-49626-x",

language = "English (US)",

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Karim, AS, Brown, DM, Archuleta, CM, Grannan, S, Aristilde, L , Goyal, Y , Leonard, JN , Mangan, NM , Prindle, A , Rocklin, GJ , Tyo, KJ, Zoloth, LS, Jewett, MC, Calkins, SC, Kamat, NP , Tullman-Ercek, D & Lucks, JB 2024, 'Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists', Nature communications, vol. 15, no. 1, 5425. https://doi.org/10.1038/s41467-024-49626-x

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AU - Archuleta, Chloé M.

AU - Grannan, Sharisse

AU - Aristilde, Ludmilla

AU - Goyal, Yogesh

AU - Leonard, Joshua N

AU - Mangan, Niall M.

AU - Prindle, Arthur

AU - Rocklin, Gabriel J.

AU - Tyo, Keith J.

AU - Zoloth, Laurie S

AU - Jewett, Michael Christopher

AU - Calkins, Susanna C

AU - Kamat, Neha P.

AU - Tullman-Ercek, Danielle

AU - Lucks, Julius B.

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Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists

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