Deconstructing the skin: Cytoarchitectural determinants of epidermal morphogenesis

Cory L. Simpson; Dipal M. Patel; Kathleen J. Green

doi:10.1038/nrm3175

Deconstructing the skin: Cytoarchitectural determinants of epidermal morphogenesis

Cory L. Simpson, Dipal M. Patel, Kathleen J. Green^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

314 Scopus citations

Abstract

To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body's most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the cornified layers, they completely reorganize their adhesive junctions and cytoskeleton. These architectural components are more than just rivets and scaffolds they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation.

Original language	English (US)
Pages (from-to)	565-580
Number of pages	16
Journal	Nature Reviews Molecular Cell Biology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1038/nrm3175
State	Published - Sep 2011

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm3175

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title = "Deconstructing the skin: Cytoarchitectural determinants of epidermal morphogenesis",

abstract = "To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body's most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the cornified layers, they completely reorganize their adhesive junctions and cytoskeleton. These architectural components are more than just rivets and scaffolds they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation.",

author = "Simpson, {Cory L.} and Patel, {Dipal M.} and Green, {Kathleen J.}",

note = "Funding Information: The authors would like to thank M. Amagai, J. Jones, T. Lechler and T. Magin for critical reading of the manuscript and/or advice on figures. We also apologize to our colleagues whose work we were unable to include owing to space limitations. The authors are supported by US National Institutes of Health grants AR043380, AR041836 and CA122151, the Leducq Foundation and the J.L. Mayberry Endowment to K.J.G.",

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Deconstructing the skin: Cytoarchitectural determinants of epidermal morphogenesis

Abstract

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