Abstract
Tactile information available to the rat vibrissal system begins as external forces that cause whisker deformations, which in turn excite mechanoreceptors in the follicle. Despite the fundamental mechanical origin of tactile information, primary sensory neurons in the trigeminal ganglion (Vg) have often been described as encoding the kinematics (geometry) of object contact. Here we aimed to determine the extent to which Vg neurons encode the kinematics vs. mechanics of contact. We used models of whisker bending to quantify mechanical signals (forces and moments) at the whisker base while simultaneously monitoring whisker kinematics and recording single Vg units in both anesthetized rats and awake, body restrained rats. We employed a novel manual stimulation technique to deflect whiskers in a way that decouples kinematics from mechanics, and used Generalized Linear Models (GLMs) to show that Vg neurons more directly encode mechanical signals when the whisker is deflected in this decoupled stimulus space.
Original language | English (US) |
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Article number | e13969 |
Journal | eLife |
Volume | 5 |
DOIs | |
State | Published - Jun 27 2016 |
Funding
National Science Foundation IOS-0818414, IOS-0846088, EFRI-0938007, DGE-0903637, National Institute of Neurological Disorders and Stroke, R01-NS093585, National Institutes of Health T32-HD0578, F31-NS092335, Air Force Office of Scientific Research, 32 CFR 168a
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology