Decreased muscle speed, strength and fatigability following two hours of tourniquet-induced ischaemia

Richard L. Lieber*, Robert A. Pedowitz, Jan Fridén, David H. Gershuni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Contractile and morphological properties of the rabbit tibialis anterior muscle were measured 48 hours following a two-hour ischaemic episode. Ischaemia was induced using a specially-designed pneumatic tourniquet placed on the rabbit thigh. Maximum tetanic tension of muscle subjected to ischaemia (381 ± 77 g) was only about 30% of the tension generated by control muscles (1 212 ± 67 g). The rate of rise of tetanic tension of muscles subjected to ischaemia (15.9 ± 3 g/ms) was only 33% of control values (44.5 ± 5.9 g/ms). Muscle fatigue index increased significantly from 0.22 ± 0.7 in control muscles to 0.55 ± 0.09 in ischaemic muscles suggesting that muscles subjected to ischaemia had a greater endurance capacity than control muscles. Morphologically, focal necrotic regions and inflammatory cells were observed in ischaemic muscle fibers. Taken together, these data are consistent with selective damage to the fast glycolytic muscle fibers within the ischaemic tibialis anterior muscles. Thus, ischaemia results in overall decreased muscle speed, strength and fatigability.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Issue number2
StatePublished - 1992


  • Fatigue
  • Fiber types
  • Ischaemia
  • Skeletal muscle
  • Tourniquet

ASJC Scopus subject areas

  • General Medicine


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