Decreased survival in necrotizing enterocolitis is significantly associated with neonatal and maternal blood group: The AB isoagglutinin hypothesis

T. Thomson, O. Habeeb, P. J. Dechristopher, L. Glynn, S. Yong, J. Muraskas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective:To determine the effect of neonatal and maternal blood group on the mortality risk from necrotizing enterocolitis (NEC).Study Design:Retrospective chart review of all neonates admitted to the neonatal intensive care unit over 24 years. Data on birth date, gestational age, maternal/neonatal blood group, number of transfusions, and survival time (defined as date of birth to date of death/discharge) were collected on those with NEC.Result:276 neonates with Bell stage II-III NEC were analyzed. AB neonates had a significantly higher risk of mortality from NEC compared with other blood groups (HR 2.87; 95% CI 1.40 to 5.89; P=0.003). Multivariate analysis showed AB blood group to be an independent risk factor for mortality from NEC.Conclusion:Neonatal and maternal blood groups are significantly associated with a neonate's survival from NEC. The increased mortality of AB neonates may be related to factors such as neonatal blood group antigens and/or transplacental transfer of isoagglutinins.

Original languageEnglish (US)
Pages (from-to)626-630
Number of pages5
JournalJournal of Perinatology
Volume32
Issue number8
DOIs
StatePublished - Aug 2012

Keywords

  • extremely-low-birthweight
  • intestine
  • mortality
  • premature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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