Deep and quantitative top-down proteomics in clinical and translational research

Neil L. Kelleher; Paul M. Thomas; Ioanna Ntai; Philip D. Compton; Richard D. Leduc

doi:10.1586/14789450.2014.976559

Deep and quantitative top-down proteomics in clinical and translational research

Neil L. Kelleher^*, Paul M. Thomas, Ioanna Ntai, Philip D. Compton, Richard D. Leduc

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

Original language	English (US)
Pages (from-to)	649-651
Number of pages	3
Journal	Expert Review of Proteomics
Volume	11
Issue number	6
DOIs	https://doi.org/10.1586/14789450.2014.976559
State	Published - Dec 1 2014

Keywords

clinical
proteomics
quantitative
top-down
translational

ASJC Scopus subject areas

Molecular Biology
Biochemistry

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10.1586/14789450.2014.976559

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abstract = "It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.",

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AU - Kelleher, Neil L.

AU - Thomas, Paul M.

AU - Ntai, Ioanna

AU - Compton, Philip D.

AU - Leduc, Richard D.

N1 - Funding Information: This study was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM067193. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2014 Informa UK, Ltd.

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N2 - It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

AB - It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

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KW - proteomics

KW - quantitative

KW - top-down

KW - translational

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Deep and quantitative top-down proteomics in clinical and translational research

Abstract

Keywords

ASJC Scopus subject areas

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