Deep and quantitative top-down proteomics in clinical and translational research

Neil L. Kelleher*, Paul M. Thomas, Ioanna Ntai, Philip D. Compton, Richard D. Leduc

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

Original languageEnglish (US)
Pages (from-to)649-651
Number of pages3
JournalExpert Review of Proteomics
Issue number6
StatePublished - Dec 1 2014


  • clinical
  • proteomics
  • quantitative
  • top-down
  • translational

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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