Deep and quantitative top-down proteomics in clinical and translational research

Neil L Kelleher*, Paul Martin Thomas, Ioanna Ntai, Philip D Compton, Richard D. Leduc

*Corresponding author for this work

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

Original languageEnglish (US)
Pages (from-to)649-651
Number of pages3
JournalExpert Review of Proteomics
Volume11
Issue number6
DOIs
StatePublished - Jan 1 2014

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Keywords

  • clinical
  • proteomics
  • quantitative
  • top-down
  • translational

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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