Deep evolutionary conservation of autism-related genes

Hagai Y. Shpigler, Michael C. Saul, Frida Corona, Lindsey Block, Amy Cash Ahmed, Sihai D. Zhao, Gene E. Robinson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

E. O. Wilson proposed in Sociobiology that similarities between human and animal societies reflect common mechanistic and evolutionary roots. When introduced in 1975, this controversial hypothesis was beyond science’s ability to test. We used genomic analyses to determine whether superficial behavioral similarities in humans and the highly social honey bee reflect common molecular mechanisms. Here, we report that gene expression signatures for individual bees unresponsive to various salient social stimuli are significantly enriched for autism spectrum disorder-related genes. These signatures occur in the mushroom bodies, a high-level integration center of the insect brain. Furthermore, our finding of enrichment was unique to autism spectrum disorders; brain gene expression signatures from other honey bee behaviors do not show this enrichment, nor do datasets from other human behavioral and health conditions. These results demonstrate deep conservation for genes associated with a human social pathology and individual differences in insect social behavior, thus providing an example of how comparative genomics can be used to test sociobiological theory.

Original languageEnglish (US)
Pages (from-to)9653-9658
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number36
DOIs
StatePublished - Sep 5 2017

Keywords

  • Autism
  • Evolution
  • Honey bee
  • Social behavior
  • Transcriptomics

ASJC Scopus subject areas

  • General

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