Deep Learning-based Spectroscopic Single-molecule Localization Microscopy for Simultaneous Multicolor Imaging

Sunil Kumar Gaire*, Ethan Flowerday, Jane Frederick, Ruyi Gong, Sravya Prabhala, Leslie Ying, Hao F. Zhang, Vadim Backman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a deep-learning-based computational approach for multicolor spectroscopic single-molecule localization microscopy. Artificial neural networks trained on simulated data to localize the stochastically blinking single-molecules and enhance the corresponding emission spectra show improved simultaneous multicolor imaging.

Original languageEnglish (US)
Title of host publicationComputational Optical Sensing and Imaging, COSI 2022
PublisherOptica Publishing Group (formerly OSA)
ISBN (Electronic)9781557528209
StatePublished - 2022
EventComputational Optical Sensing and Imaging, COSI 2022 - Vancouver, Canada
Duration: Jul 11 2022Jul 15 2022

Publication series

NameOptics InfoBase Conference Papers

Conference

ConferenceComputational Optical Sensing and Imaging, COSI 2022
Country/TerritoryCanada
CityVancouver
Period7/11/227/15/22

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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