Deep Learning-based Spectroscopic Single-molecule Localization Microscopy for Simultaneous Multicolor Imaging

Sunil Kumar Gaire*, Ethan Flowerday, Jane Frederick, Ruyi Gong, Sravya Prabhala, Leslie Ying, Hao F. Zhang, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

We present a deep-learning-based computational approach for multicolor spectroscopic single-molecule localization microscopy. Artificial neural networks trained on simulated data to localize the stochastically blinking single-molecules and enhance the corresponding emission spectra show improved simultaneous multicolor imaging.

Original languageEnglish (US)
JournalOptics InfoBase Conference Papers
StatePublished - 2022
EventComputational Optical Sensing and Imaging, COSI 2022 - Vancouver, Canada
Duration: Jul 11 2022Jul 15 2022

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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