Deep Learning for Daily Monitoring of Parkinson’s Disease Outside the Clinic Using Wearable Sensors

Roozbeh Atri, Kevin Urban, Barbara Marebwa, Tanya Simuni, Caroline Tanner, Andrew Siderowf, Mark Frasier, Magali Haas, Lee Lancashire*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Now that wearable sensors have become more commonplace, it is possible to monitor individual healthcare-related activity outside the clinic, unleashing potential for early detection of events in diseases such as Parkinson’s disease (PD). However, the unsupervised and “open world” nature of this type of data collection make such applications difficult to develop. In this proof-of-concept study, we used inertial sensor data from Verily Study Watches worn by individuals for up to 23 h per day over several months to distinguish between seven subjects with PD and four without. Since motor-related PD symptoms such as bradykinesia and gait abnormalities typically present when a PD subject is walking, we initially used human activity recognition (HAR) techniques to identify walk-like activity in the unconstrained, unlabeled data. We then used these “walk-like” events to train one-dimensional convolutional neural networks (1D-CNNs) to determine the presence of PD. We report classification accuracies near 90% on single 5-s walk-like events and 100% accuracy when taking the majority vote over single-event classifications that span a duration of one day. Though based on a small cohort, this study shows the feasibility of leveraging unconstrained wearable sensor data to accurately detect the presence or absence of PD.

Original languageEnglish (US)
Article number6831
JournalSensors
Volume22
Issue number18
DOIs
StatePublished - Sep 2022

Funding

The sensor data used in this study were obtained by Michael J Fox Foundation (MJFF) in collaboration with Verily for the Parkinson’s Progression Markers Initiative (PPMI) study. This work was jointly funded by Cohen Veterans Bioscience (COH-0003) and a generous grant from the Michael J Fox Foundation as part of the Parkinson’s Progression Markers Initiative. (MJFF-020749).

Keywords

  • Parkinson’s disease
  • deep learning
  • human activity recognition
  • wearable sensors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Information Systems
  • Instrumentation
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering
  • Biochemistry

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