Deep tissue injury rat model for pressure ulcer research on spinal cord injury

Fang Lin, Atek Pandya, Andrew Cichowski, Mauli Modi, Briana Reprogle, Dongkeun Lee, Norio Kadono, Mohsen Makhsous*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Many rat/mouse pressure ulcer (PU) models have been developed to test different hypotheses to gain deeper understanding of various causative risk factors, the progress of PUs, and assessing effectiveness of potential treatment modalities. The recently emphasized deep tissue injury (DTI) mechanism for PU formation has received increased attention and several studies reported findings on newly developed DTI animal models. However, concerns exist for the clinical relevance and validity of these models, especially when the majority of the reported rat PU/DTI models were not built upon SCI animals and many of the DTI research did not simulate well the clinical observation. In this study, we propose a rat PU and DTI model which is more clinically relevant by including chronic SCI condition into the rat PU model and to simulate the role of bony prominence in DTI formation by using an implant on the bone-tissue interface. Histological data and imaging findings confirmed that the condition of chronic SCI had significant effect on pressure induced tissue injury in a rat PU model and the including a simulated bony prominence in rat DTI model resulted in significantly greater injury in deep muscle tissue. Further integration of the SCI condition and the simulated bony prominence would result a rat PU/DTI model which can simulate even more accurately the clinical phenomenon and yield more clinically relevant findings.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalJournal of Tissue Viability
Volume19
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Animal model
  • Deep tissue injury
  • Histology
  • Implant
  • Spinal cord injury

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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