TY - JOUR
T1 - Deficit of supramodal executive control of attention in schizophrenia
AU - Spagna, Alfredo
AU - He, Genxia
AU - Jin, Shengchun
AU - Gao, Liling
AU - Mackie, Melissa Ann
AU - Tian, Yanghua
AU - Wang, Kai
AU - Fan, Jin
N1 - Funding Information:
This work was supported by the National Nature Science Foundation of China (grant numbers No. 81471117 , 81671354 ), the National Basic Research Program of China (grant number No. 2015CB856400 ) and National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No. 2015BAI13B01 ) to Y.T. J.F. was supported by the National Institute of Mental Health of the National Institutes of Health (NIH) (grant number MH094305 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors report no financial or other conflict of interest relevant to the subject of this article.
Publisher Copyright:
© 2017 Elsevier Ltd
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Although a deficit in executive control of attention is one of the hallmarks in schizophrenia that has significant impact on everyday functioning due to its relationship with thought processing, whether this deficit occurs across modalities, i.e., is supramodal, remains unclear. To investigate the supramodal mechanism in SZ, we examined cross-modal correlations between visual and auditory executive control of attention in a group of patients with schizophrenia (SZ, n = 55) compared to neurotypical controls (NC, n = 55). While the executive control effects were significantly correlated between the two modalities in the NC group, these effects were not correlated in the SZ group, with a significant group difference in the correlation. Further, the inconsistency and magnitude of the cross-modal executive control effects were significantly larger in the SZ group compared to the NC group. Together, these results suggest that there is a disruption of a common supramodal executive control mechanism in patients with schizophrenia, which may be related to the thought processing disorder characterizing the disorder.
AB - Although a deficit in executive control of attention is one of the hallmarks in schizophrenia that has significant impact on everyday functioning due to its relationship with thought processing, whether this deficit occurs across modalities, i.e., is supramodal, remains unclear. To investigate the supramodal mechanism in SZ, we examined cross-modal correlations between visual and auditory executive control of attention in a group of patients with schizophrenia (SZ, n = 55) compared to neurotypical controls (NC, n = 55). While the executive control effects were significantly correlated between the two modalities in the NC group, these effects were not correlated in the SZ group, with a significant group difference in the correlation. Further, the inconsistency and magnitude of the cross-modal executive control effects were significantly larger in the SZ group compared to the NC group. Together, these results suggest that there is a disruption of a common supramodal executive control mechanism in patients with schizophrenia, which may be related to the thought processing disorder characterizing the disorder.
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U2 - 10.1016/j.jpsychires.2017.11.002
DO - 10.1016/j.jpsychires.2017.11.002
M3 - Article
C2 - 29172174
AN - SCOPUS:85034790980
SN - 0022-3956
VL - 97
SP - 22
EP - 29
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -
