Deficits in social knowledge following damage to ventromedial prefrontal cortex

Linda W Y Mah, Miriam Courtney Arnold, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Patients with damage to the frontal lobes frequently exhibit impaired social behavior, but it is not clear which specific processes are disrupted. The authors investigated the ability to interpret nonverbal emotional expression in patients with lesions involving ventromedial (N = 20) or dorsolateral prefrontal cortex (N = 9) and in healthy volunteers (N = 23). As hypothesized, only patients with ventromedial prefrontal lesions showed impaired task performance relative to normal comparison subjects. These results suggest that deficits in social knowledge, namely difficulty interpreting nonverbal emotional expression, contribute to the aberrant social behavior observed following ventromedial prefrontal cortex lesions.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
StatePublished - 2005

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Deficits in social knowledge following damage to ventromedial prefrontal cortex'. Together they form a unique fingerprint.

Cite this