Defining a Therapeutic Dose of Peripheral Blood Stem Cells

James G. Bender*, L. Bik To, Stephanie Williams, Lee S. Schwartzberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

285 Scopus citations

Abstract

Peripheral blood stem cells (PBSC) are now used extensively to provide rapid and durable hematopoietic reconstitution following supralethal myeloablative therapies. A major clinical issue is the quantitation of the cells responsible for reconstitution. We review here published reports of transplants using the measurement of mononuclear cells and granulocyte-macrophage colony-forming units (CFU-GM) to quantitate PBSC. In addition, we present data from three institutions where hematopoietic recovery is correlated with doses of CFU-GM or CD34+ cells. These data suggest doses of 20 X 104 CFU-GM or 2 X 106 CD34+ cells/kg body weight that provide rapid engraftment of neutrophils and platelets.

Original languageEnglish (US)
Pages (from-to)329-341
Number of pages13
JournalJournal of Hematotherapy and Stem Cell Research
Volume1
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Hematology

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