Defining and measuring reproductive concerns of female cancer survivors.

Lari Wenzel*, Aysun Dogan-Ates, Rana Habbal, Ross Berkowitz, Donald P. Goldstein, Marilyn Bernstein, Brenda Coffey Kluhsman, Kathryn Osann, Edward Newlands, Michael J. Seckl, Barry Hancock, David Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


Although women diagnosed with cancer during their childbearing years are at significant risk for infertility, we know little about the relationship between infertility and long-term quality of life (QOL). To examine these relationships, we assessed psychosocial and reproductive concerns and QOL in 231 female cancer survivors. Greater reproductive concerns were significantly associated with lower QOL on numerous dimensions (P<.001). In a multiple regression model, social support, gynecologic problems, and reproductive concerns accounted for 63% of the variance in QOL scores. Women who reported wanting to conceive after cancer, but were not able to, reported significantly more reproductive concerns than those who were able to reproduce after cancer (P<.001). These preliminary data suggest that at least for vulnerable subgroups, the issue of reproductive concerns is worthy of additional investigation to assist cancer survivors living with the threat or reality of infertility.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalJournal of the National Cancer Institute. Monographs
Issue number34
StatePublished - 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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