Defining intrinsic vs. extrinsic atopic dermatitis

Chante Karimkhani, Jonathan I. Silverberg, Robert P. Dellavalle*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

14 Scopus citations


Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition characterized by eczematous lesions, i.e. illdemarcated erythematous patches and plaques. AD is commonly associated with elevated immunoglobulin E (IgE) and atopic disorders, such as asthma, hay fever, and food allergies. Rackemann and Mallory were some of the first to distinguish between asthma based on the presence (“extrinsic”) or absence (“intrinsic”) of allergy. This distinction has subsequently been applied to AD based on the presence (“extrinsic”) or absence (“intrinsic”) of increased IgE and atopic disease. Although the distinction between intrinsic and extrinsic AD is widely used, it remains controversial.

Original languageEnglish (US)
JournalDermatology online journal
Issue number6
StatePublished - 2015


  • Allergy
  • Asthma
  • Atopic dermatitis
  • Eczema
  • Fillagrin

ASJC Scopus subject areas

  • Dermatology


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