Defining the functional boundaries of the murine α1,3- fucosyltransferase Fut7 reveals a remarkably compact locus

Mark E. Ebel; Geoffrey S. Kansas

doi:10.1074/jbc.M113.511790

Defining the functional boundaries of the murine α1,3- fucosyltransferase Fut7 reveals a remarkably compact locus

Mark E. Ebel, Geoffrey S. Kansas^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Fut7 gene expression is tightly regulated and controls leukocyte traffic. Results: A 12.7 kb genomic interval controls Fut7 gene expression in all cell types. Conclusion: This interval therefore represents the functional boundaries of the Fut7 locus. Significance: All cis-acting genetic elements that control Fut7 expression are within this genomic interval.

Original language	English (US)
Pages (from-to)	6341-6349
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M113.511790
State	Published - Mar 7 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.511790

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abstract = "Background: Fut7 gene expression is tightly regulated and controls leukocyte traffic. Results: A 12.7 kb genomic interval controls Fut7 gene expression in all cell types. Conclusion: This interval therefore represents the functional boundaries of the Fut7 locus. Significance: All cis-acting genetic elements that control Fut7 expression are within this genomic interval.",

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AB - Background: Fut7 gene expression is tightly regulated and controls leukocyte traffic. Results: A 12.7 kb genomic interval controls Fut7 gene expression in all cell types. Conclusion: This interval therefore represents the functional boundaries of the Fut7 locus. Significance: All cis-acting genetic elements that control Fut7 expression are within this genomic interval.

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Defining the functional boundaries of the murine α1,3- fucosyltransferase Fut7 reveals a remarkably compact locus

Abstract

ASJC Scopus subject areas

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