@article{e3ec055fdf334203b135b4961b20af4c,
title = "Defining Treatment Response and Remission in Youth Anxiety: A Signal Detection Analysis With the Multidimensional Anxiety Scale for Children",
abstract = "Objective: To determine the percent reduction cutoffs on the Multidimensional Anxiety Scale for Children (MASC) that optimally predict treatment response and remission in youth with anxiety disorders. Method: Youths and their parents completed the MASC-C/P before and after treatment, and the Anxiety Disorders Interview Schedule for DSM-IV–Child and Parent Versions (ADIS-IV-C/P) and the Clinical Global Impression–Improvement Scale (CGI-I) were administered by independent evaluators. Treatment response and remission were defined by post-treatment ratings on the CGI-I and the ADIS-IV-C/P, respectively. Quality receiver operating characteristic methods determined the optimal cutoff on the MASC-P for predicting overall remission (loss of all study entry diagnoses) and optimal percent reductions on the MASC-P for predicting treatment response and remission of separation anxiety, social anxiety, and generalized anxiety. Results: A post-treatment raw score of 42 optimally predicted remission. A reduction of 35% on the total MASC-P predicted treatment response. A reduction of 30% on the Separation Anxiety/Panic subscale of the MASC-P predicted separation anxiety remission. A reduction of 35% on the Social Anxiety subscale of the MASC-P predicted social anxiety remission. The MASC did not evidence a cutoff for remission of generalized anxiety disorder. Conclusion: MASC cutoffs can facilitate comparison across studies and guide practice, aiding clinicians in assessing progress and informing treatment plans.",
keywords = "Multidimensional Anxiety Scale for Children, child anxiety, clinical assessment, measurement, treatment outcome",
author = "Palitz, {Sophie A.} and Caporino, {Nicole E.} and McGuire, {Joseph F.} and John Piacentini and Albano, {Anne Marie} and Boris Birmaher and Walkup, {John Timothy} and Compton, {Scott N.} and Ginsburg, {Golda S.} and Kendall, {Philip C.}",
note = "Funding Information: This research was supported by grants from the National Institute of Mental Health (NIMH): U01 MH064089 to Dr. Walkup; U01 MH64092 to Dr. Albano; U01 MH64003 to Dr. Birmaher; U01 MH63747 to Dr. Kendall; U01 MH64088 to Dr. Piacentini; and U01 MH064003 to Dr. Compton. Views expressed within this article represent those of the authors and are not intended to represent the position of the NIMH, the National Institutes of Health, or the US Department of Health and Human Services. Sertraline and matching placebo were supplied free of charge by Pfizer. The Anxiety Disorders Interview Schedule, Child and Parent Versions were provided at no cost to the investigators in this study. Funding Information: Disclosure: Dr. Caporino has received grant funding from the American Psychological Foundation and the Anna-Maria and Stephen Kellen Foundation. She also has received an honorarium from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Dr. McGuire has received support from the Tourette Association of America, the American Academy of Neurology, the Brain Research Foundation, and the NIMH. He has received royalties from Elsevier and has served as a consultant for Bracket. Dr. Piacentini has received grant or research support from the NIMH, the TLC Foundation for Body-Focused Repetitive Behaviors, the Tourette Association of America, the Pettit Family Foundation, and Pfizer Pharmaceuticals through the Duke University Clinical Research Institute Network. He is a co-author of the Child OCD Impact Scale-Revised (COIS-R), the Child Anxiety Impact Scale–Revised (CAIS-R), the Parent Tic Questionnaire (PTQ), and the Premonitory Urge for Tics Scale (PUTS) assessment tools, all of which are in the public domain; therefore, no royalties are received. He has received royalties from Guilford Press and Oxford University Press. He has served on the speakers{\textquoteright} bureau of the Tourette Association of America, the International Obsessive-Compulsive Disorder Foundation, and the TLC Foundation for Body-Focused Repetitive Behaviors. Dr. Albano has received royalties from Oxford University Press for the Anxiety Disorders Interview Schedule, Child and Parent Versions . She has received an Editor{\textquoteright}s Honorarium from the American Psychological Association. Dr. Birmaher has received research support from the NIMH. He has or will receive royalties from Random House, Inc., Lippincott Williams and Wilkins, and UpToDate. Dr. Walkup has received research support from the Tourette Syndrome Association of America and the Hartwell Foundation. He has received honoraria and travel expenses for speaking engagements and meetings sponsored by the Tourette Association of America. He has received royalties from Guilford Press and Oxford University Press for multi-author books published about Tourette{\textquoteright}s syndrome and from Wolters Kluwer for CME activity on childhood anxiety. He has served as an unpaid advisor to the Anxiety Disorders Association of America and the Trichotillomania Learning Center. He has served as a paid speaker for the Tourette Syndrome–Center for Disease Control and Prevention outreach educational programs, the American Academy of Child and Adolescent Psychiatry, and the American Psychiatric Association. Dr. Compton has received research support from the NIMH, NC GlaxoSmithKline Foundation, Pfizer, and Mursion, Inc. He has served as a consultant for Shire and Mursion, Inc. He has received honoraria from the Nordic Long-Term OCD Treatment Study Research Group and the Centre for Child and Adolescent Mental Health, Eastern and Southern Norway. He has served on the scientific advisory board of the Tourette Association of America and Mursion, Inc. He has presented expert testimony for Duke University. Dr. Ginsburg has received support from the NIMH and from the US Department of Education/Institute of Education Sciences. Dr. Kendall has received support from the NIMH and the NICHD. He has received royalties from the sales of materials related to the treatment of anxiety disorders in youth (e.g., Guilford Press; Workbook Publishing; Gyldendal Norsk; Gyldendal Akademisk). Ms. Palitz reports no biomedical financial interests or potential conflicts of interest. New research ",
year = "2018",
month = jun,
doi = "10.1016/j.jaac.2018.03.013",
language = "English (US)",
volume = "57",
pages = "418--427",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "6",
}