Definition der pharmakoresistenten Epilepsie: Konsensusvorschlag der ad hoc-Task Force der ILAE-Kommission für Therapeutische Strategien

Translated title of the contribution: Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE commission on therapeutic strategies

P. Kwan*, A. Arzimanoglou, A. T. Berg, M. J. Brodie, W. A. Hauser, G. Mathern, S. L. Moshé, E. Perucca, S. Wiebe, J. French

*Corresponding author for this work

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy. The overall framework of the definition has two hierarchical levels: Level 1 provides a general scheme to categorize response to each therapeutic intervention, including a minimum dataset of knowledge about the intervention that would be needed; Level 2 provides a core definition of drug resistant epilepsy using a set of essential criteria based on the categorization of response (from Level 1) to trials of antiepileptic drugs. It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom. This definition can be further refined when new evidence emerges. The rationale behind the definition and the principles governing its proper use are discussed, and examples to illustrate its application in clinical practice are provided.

Translated title of the contributionDefinition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE commission on therapeutic strategies
Original languageGerman
Pages (from-to)372-381
Number of pages10
JournalAktuelle Neurologie
Volume37
Issue number8
DOIs
StatePublished - Nov 25 2010

Keywords

  • definition
  • drug resistance
  • epilepsy
  • international league against epilepsy
  • intractable
  • refractory

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE commission on therapeutic strategies'. Together they form a unique fingerprint.

  • Cite this

    Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Hauser, W. A., Mathern, G., Moshé, S. L., Perucca, E., Wiebe, S., & French, J. (2010). Definition der pharmakoresistenten Epilepsie: Konsensusvorschlag der ad hoc-Task Force der ILAE-Kommission für Therapeutische Strategien. Aktuelle Neurologie, 37(8), 372-381. https://doi.org/10.1055/s-0030-1265943