Abstract
We report the synthesis of a degradable polyphosphoramidate via ring-opening metathesis polymerization (ROMP) with the Grubbs initiator (IMesH2)(C5H5N)2(Cl)2Ru═CHPh. Controlled ROMP of a low ring strain diazaphosphepine-based cyclic olefin was achieved at low temperatures to afford well-defined polymers that readily undergo degradation in acidic conditions via the cleavage of the acid-labile phosphoramidate linkages. The diazaphosphepine monomer was compatible in random and block copolymerizations with phenyl and oligo(ethylene glycol) bearing norbornenes. This approach introduced partial or complete degradability into the polymer backbones. With this chemistry, we accessed amphiphilic poly(diazaphosphepine-norbornene) copolymers that could be used to prepare micellar nanoparticles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1417-1422 |
| Number of pages | 6 |
| Journal | ACS Macro Letters |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 20 2020 |
Funding
N.C.G. acknowledges support of this research from the NIH through the NHLBI (R01HL139001). Additional support was provided by the IMSERC at Northwestern University, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the State of Illinois, and the International Institute for Nanotechnology (IIN).
ASJC Scopus subject areas
- Materials Chemistry
- Polymers and Plastics
- Inorganic Chemistry
- Organic Chemistry