Delayed-enhancement magnetic resonance imaging at 3.0 T using 0.15 mmol/kg of contrast agent for the assessment of chronic myocardial infarction

Jun Yang*, Heng Ma, Jing Liu, Chunxiao Wang, Yinghong Shi, Haizhu Xie, Futao Huo, Fengli Liu, Kai Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective A recent international, multicenter, double-blinded, randomized trial shows delayed-enhanced magnetic resonance imaging (DE-MRI) using contrast doses of ≥0.2 mmol/kg is effective in the detection and assessment of myocardial infarction (MI), and 0.1 mmol/kg is not enough; intermediate doses between 0.1 and 0.2 mmol/kg have not been tested. The aim of this study was to prospectively test the performance of DE-MRI using 0.15 mmol/kg of contrast agent for the detection of MI. Materials and methods A total of 31 consecutive patients with chronic MI underwent DE-MRI at 3.0 T using both 0.15 mmol/kg and 0.2 mmol/kg of contrast agent in random order and on separate days. Infarction segment and infarction size were compared on DE-MRI images using a 17-segment model. Bland-Altman analysis was used to analyze correlation and agreement between global infarct sizes. Results DE-MRI showed enhanced myocardium in all the 31 patients with chronic MI. There was no significant difference between the 0.15 mmol/kg and 0.2 mmol/kg images in all 31 patients based on the infarction segment (7.87 ± 2.72 vs. 7.81 ± 2.64, respectively; p = 0.33). There was no significant difference between the infarction size obtained from 0.15 mmol/kg acquisition and that from 0.2 mmol/kg acquisition (16.3 ± 7.8% vs. 16.4 ± 7.9%, respectively; p = 0.87). A strong correlation between the infarction size obtained from 0.15 mmol/kg acquisition and that from 0.2 mmol/kg acquisition was indicated through Bland-Altman analysis. Conclusion DE-MRI at 3.0 T using 0.15 mmol/kg of contrast agent is effective for the assessment of MI.

Original languageEnglish (US)
Pages (from-to)778-782
Number of pages5
JournalEuropean journal of radiology
Volume83
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Imaging
  • Magnetic resonance imaging
  • Myocardial infarction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Delayed-enhancement magnetic resonance imaging at 3.0 T using 0.15 mmol/kg of contrast agent for the assessment of chronic myocardial infarction'. Together they form a unique fingerprint.

Cite this