TY - JOUR
T1 - Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis
T2 - Findings at different radiographic stages of disease and relationship to malalignment
AU - Williams, Ashley
AU - Sharma, Leena
AU - McKenzie, Charles A.
AU - Prasad, Pottumarthi V.
AU - Burstein, Deborah
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/11
Y1 - 2005/11
N2 - Objective. Delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) is used to examine the distribution of glycosaminoglycan in cartilage. This study sought to characterize dGEMRIC in the evaluation of knee osteoarthritis (OA) according to various radiographically determined disease parameters, a nd to examine the relationship between alignment of the knee joint and the lateral:medial dGEMRIC ratio. Methods. Thirty-one patients with knee OA underwent MRI with a dGEMRIC protocol at 1.5T. Semi-flexed knee radiographs and full-limb radiographs were also obtained for assessment of alignment. Results. Compartments of the knee joint without joint space narrowing had a higher dGEMRIC index than those with any level of narrowing (mean 408 msec versus 365 msec; P = 0.001). In knees with 1 unnarrowed (spared) and 1 narrowed (diseased) compartment, the dGEMRIC index was greater in the spared versus the diseased compartment (mean 395 msec versus 369 msec; P = 0.001). In spared compartments, there was a trend toward a lower dGEMRIC index with increasing Kellgren/Lawrence (K/L) radiographic severity grade; the spared compartments of knees with a K/L grade 2 had a higher dGEMRIC index than those of knees with a K/L grade 4 (mean 425 msec versus 371 msec; P < 0.05). There was a range of dGEMRIC values in the spared compartments within a given K/L grade, demonstrating biochemical differentiation of disease in radiographically comparable compartments. Almost all compartments with narrowing had dGEMRIC indices of <400 msec. Valgus-aligned knees tended to have lower dGEMRIC values laterally, and varus-aligned knees tended to have lower dGEMRIC values medially; as a continuous variable, alignment correlated with the lateral:media) dGEMRIC ratio (Pearson's R = 0.43, P = 0.02). Conclusion. The biochemical information provided by dGEMRIC scans may augment radiography by improving the differentiation of disease status within a given radiographic grade, especially in early OA.
AB - Objective. Delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) is used to examine the distribution of glycosaminoglycan in cartilage. This study sought to characterize dGEMRIC in the evaluation of knee osteoarthritis (OA) according to various radiographically determined disease parameters, a nd to examine the relationship between alignment of the knee joint and the lateral:medial dGEMRIC ratio. Methods. Thirty-one patients with knee OA underwent MRI with a dGEMRIC protocol at 1.5T. Semi-flexed knee radiographs and full-limb radiographs were also obtained for assessment of alignment. Results. Compartments of the knee joint without joint space narrowing had a higher dGEMRIC index than those with any level of narrowing (mean 408 msec versus 365 msec; P = 0.001). In knees with 1 unnarrowed (spared) and 1 narrowed (diseased) compartment, the dGEMRIC index was greater in the spared versus the diseased compartment (mean 395 msec versus 369 msec; P = 0.001). In spared compartments, there was a trend toward a lower dGEMRIC index with increasing Kellgren/Lawrence (K/L) radiographic severity grade; the spared compartments of knees with a K/L grade 2 had a higher dGEMRIC index than those of knees with a K/L grade 4 (mean 425 msec versus 371 msec; P < 0.05). There was a range of dGEMRIC values in the spared compartments within a given K/L grade, demonstrating biochemical differentiation of disease in radiographically comparable compartments. Almost all compartments with narrowing had dGEMRIC indices of <400 msec. Valgus-aligned knees tended to have lower dGEMRIC values laterally, and varus-aligned knees tended to have lower dGEMRIC values medially; as a continuous variable, alignment correlated with the lateral:media) dGEMRIC ratio (Pearson's R = 0.43, P = 0.02). Conclusion. The biochemical information provided by dGEMRIC scans may augment radiography by improving the differentiation of disease status within a given radiographic grade, especially in early OA.
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U2 - 10.1002/art.21388
DO - 10.1002/art.21388
M3 - Article
C2 - 16255024
AN - SCOPUS:27744573808
SN - 0004-3591
VL - 52
SP - 3528
EP - 3535
JO - Arthritis and rheumatism
JF - Arthritis and rheumatism
IS - 11
ER -