Delayed-onset profound biotnidase deficiency

B. Wolf*, R. Pomponio, K. Norrgard, I. Lott, E. R. Baumgartner, T. Suormala, V. T. Ramaekers, T. Coskun, A. Tokatli, I. Ozalp, J. Hymes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at on early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalJournal of Pediatrics
Issue number2
StatePublished - 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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