Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Gregory Aubert, David Y. Barefield, Alexis R Demonbreun, Mohun Ramratnam, Katherine S. Fallon, James L. Warner, Ann E. Rossi, Michele Hadhazy, Jonathan C. Makielski, Elizabeth M McNally*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.

Original languageEnglish (US)
Pages (from-to)251-268
Number of pages18
JournalJACC: Basic to Translational Science
Volume4
Issue number2
DOIs
StatePublished - Apr 1 2019

Fingerprint

Sulfonylurea Receptors
Myocardium
Glucose
Facilitative Glucose Transport Proteins
Glycolysis
Reperfusion Injury
Cardiac Myocytes
Wounds and Injuries

Keywords

  • ABCC9
  • ischemia
  • potassium ATP channels
  • sulfonylurea

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Aubert, Gregory ; Barefield, David Y. ; Demonbreun, Alexis R ; Ramratnam, Mohun ; Fallon, Katherine S. ; Warner, James L. ; Rossi, Ann E. ; Hadhazy, Michele ; Makielski, Jonathan C. ; McNally, Elizabeth M. / Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. In: JACC: Basic to Translational Science. 2019 ; Vol. 4, No. 2. pp. 251-268.
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Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. / Aubert, Gregory; Barefield, David Y.; Demonbreun, Alexis R; Ramratnam, Mohun; Fallon, Katherine S.; Warner, James L.; Rossi, Ann E.; Hadhazy, Michele; Makielski, Jonathan C.; McNally, Elizabeth M.

In: JACC: Basic to Translational Science, Vol. 4, No. 2, 01.04.2019, p. 251-268.

Research output: Contribution to journalArticle

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