Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Gregory Aubert; David Y. Barefield; Alexis R Demonbreun; Mohun Ramratnam; Katherine S. Fallon; James L. Warner; Ann E. Rossi; Michele Hadhazy; Jonathan C. Makielski; Elizabeth M McNally

doi:10.1016/j.jacbts.2018.11.012

Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Gregory Aubert, David Y. Barefield, Alexis R Demonbreun, Mohun Ramratnam, Katherine S. Fallon, James L. Warner, Ann E. Rossi, Michele Hadhazy, Jonathan C. Makielski, Elizabeth M McNally^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.

Original language	English (US)
Pages (from-to)	251-268
Number of pages	18
Journal	JACC: Basic to Translational Science
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2018.11.012
State	Published - Apr 2019

Keywords

ABCC9
ischemia
potassium ATP channels
sulfonylurea

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2018.11.012

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Aubert, G., Barefield, D. Y., Demonbreun, A. R., Ramratnam, M., Fallon, K. S., Warner, J. L., Rossi, A. E., Hadhazy, M., Makielski, J. C., & McNally, E. M. (2019). Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. JACC: Basic to Translational Science, 4(2), 251-268. https://doi.org/10.1016/j.jacbts.2018.11.012

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abstract = "The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.",

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AU - Ramratnam, Mohun

AU - Fallon, Katherine S.

AU - Warner, James L.

AU - Rossi, Ann E.

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AB - The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.

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Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

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Keywords

ASJC Scopus subject areas

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