Abstract
The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 251-268 |
| Number of pages | 18 |
| Journal | JACC: Basic to Translational Science |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2019 |
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Keywords
- ABCC9
- ischemia
- potassium ATP channels
- sulfonylurea
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
}
Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. / Aubert, Gregory; Barefield, David Y.; Demonbreun, Alexis R; Ramratnam, Mohun; Fallon, Katherine S.; Warner, James L.; Rossi, Ann E.; Hadhazy, Michele; Makielski, Jonathan C.; McNally, Elizabeth M.
In: JACC: Basic to Translational Science, Vol. 4, No. 2, 01.04.2019, p. 251-268.Research output: Contribution to journal › Article
TY - JOUR
T1 - Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective
AU - Aubert, Gregory
AU - Barefield, David Y.
AU - Demonbreun, Alexis R
AU - Ramratnam, Mohun
AU - Fallon, Katherine S.
AU - Warner, James L.
AU - Rossi, Ann E.
AU - Hadhazy, Michele
AU - Makielski, Jonathan C.
AU - McNally, Elizabeth M
PY - 2019/4/1
Y1 - 2019/4/1
N2 - The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.
AB - The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.
KW - ABCC9
KW - ischemia
KW - potassium ATP channels
KW - sulfonylurea
UR - http://www.scopus.com/inward/record.url?scp=85064440423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064440423&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2018.11.012
DO - 10.1016/j.jacbts.2018.11.012
M3 - Article
C2 - 31061927
AN - SCOPUS:85064440423
VL - 4
SP - 251
EP - 268
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 2
ER -