Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Gregory Aubert; David Y. Barefield; Alexis R Demonbreun; Mohun Ramratnam; Katherine S. Fallon; James L. Warner; Ann E. Rossi; Michele Hadhazy; Jonathan C. Makielski; Elizabeth M McNally

doi:10.1016/j.jacbts.2018.11.012

Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Gregory Aubert, David Y. Barefield, Alexis R Demonbreun, Mohun Ramratnam, Katherine S. Fallon, James L. Warner, Ann E. Rossi, Michele Hadhazy, Jonathan C. Makielski, Elizabeth M McNally^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.

Original language	English (US)
Pages (from-to)	251-268
Number of pages	18
Journal	JACC: Basic to Translational Science
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2018.11.012
State	Published - Apr 2019

Keywords

ABCC9
ischemia
potassium ATP channels
sulfonylurea

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.jacbts.2018.11.012

Cite this

Aubert, G., Barefield, D. Y., Demonbreun, A. R., Ramratnam, M., Fallon, K. S., Warner, J. L., Rossi, A. E., Hadhazy, M., Makielski, J. C., & McNally, E. M. (2019). Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. JACC: Basic to Translational Science, 4(2), 251-268. https://doi.org/10.1016/j.jacbts.2018.11.012

@article{076cc76b1c444a53b312a1ec3b05c521,

title = "Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective",

abstract = "The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.",

keywords = "ABCC9, ischemia, potassium ATP channels, sulfonylurea",

author = "Gregory Aubert and Barefield, {David Y.} and Demonbreun, {Alexis R} and Mohun Ramratnam and Fallon, {Katherine S.} and Warner, {James L.} and Rossi, {Ann E.} and Michele Hadhazy and Makielski, {Jonathan C.} and McNally, {Elizabeth M}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = apr,

doi = "10.1016/j.jacbts.2018.11.012",

language = "English (US)",

volume = "4",

pages = "251--268",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

AU - Aubert, Gregory

AU - Barefield, David Y.

AU - Demonbreun, Alexis R

AU - Ramratnam, Mohun

AU - Fallon, Katherine S.

AU - Warner, James L.

AU - Rossi, Ann E.

AU - Hadhazy, Michele

AU - Makielski, Jonathan C.

AU - McNally, Elizabeth M

PY - 2019/4

Y1 - 2019/4

N2 - The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.

AB - The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury.

KW - ABCC9

KW - ischemia

KW - potassium ATP channels

KW - sulfonylurea

UR - http://www.scopus.com/inward/record.url?scp=85064440423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064440423&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2018.11.012

DO - 10.1016/j.jacbts.2018.11.012

M3 - Article

C2 - 31061927

AN - SCOPUS:85064440423

SN - 2452-302X

VL - 4

SP - 251

EP - 268

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 2

ER -

Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this