Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy

Devin M. Stranford; Joshua N Leonard

doi:10.1016/bs.adgen.2017.08.002

Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy

Devin M. Stranford, Joshua N Leonard^*

^*Corresponding author for this work

Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Extracellular vesicles (EVs) are membrane-enclosed particles that are secreted by nearly all cells and play an important role in intercellular communication by transporting protein and nucleic acids between cells. EV-mediated processes shape phenomena as diverse as cancer progression, immune function, and wound healing. The natural role of EVs in encapsulating and delivering cargo to modify cellular function highlights the potential to use these particles as therapeutic delivery vehicles. In this chapter, we describe emerging strategies for EV engineering and consider how different approaches to EV production, purification, and design may impact the efficacy of EV-based therapeutics.

Original language	English (US)
Pages (from-to)	155-175
Number of pages	21
Journal	Advances in Genetics
Volume	98
DOIs	https://doi.org/10.1016/bs.adgen.2017.08.002
State	Published - Jan 1 2017

Keywords

Exosome
Extracellular vesicle
Gene delivery
Microvesicle
Nanoparticle
Targeted therapeutics

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/bs.adgen.2017.08.002

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title = "Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy",

abstract = "Extracellular vesicles (EVs) are membrane-enclosed particles that are secreted by nearly all cells and play an important role in intercellular communication by transporting protein and nucleic acids between cells. EV-mediated processes shape phenomena as diverse as cancer progression, immune function, and wound healing. The natural role of EVs in encapsulating and delivering cargo to modify cellular function highlights the potential to use these particles as therapeutic delivery vehicles. In this chapter, we describe emerging strategies for EV engineering and consider how different approaches to EV production, purification, and design may impact the efficacy of EV-based therapeutics.",

keywords = "Exosome, Extracellular vesicle, Gene delivery, Microvesicle, Nanoparticle, Targeted therapeutics",

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year = "2017",

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doi = "10.1016/bs.adgen.2017.08.002",

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T1 - Delivery of Biomolecules via Extracellular Vesicles

T2 - A Budding Therapeutic Strategy

AU - Stranford, Devin M.

AU - Leonard, Joshua N

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N2 - Extracellular vesicles (EVs) are membrane-enclosed particles that are secreted by nearly all cells and play an important role in intercellular communication by transporting protein and nucleic acids between cells. EV-mediated processes shape phenomena as diverse as cancer progression, immune function, and wound healing. The natural role of EVs in encapsulating and delivering cargo to modify cellular function highlights the potential to use these particles as therapeutic delivery vehicles. In this chapter, we describe emerging strategies for EV engineering and consider how different approaches to EV production, purification, and design may impact the efficacy of EV-based therapeutics.

AB - Extracellular vesicles (EVs) are membrane-enclosed particles that are secreted by nearly all cells and play an important role in intercellular communication by transporting protein and nucleic acids between cells. EV-mediated processes shape phenomena as diverse as cancer progression, immune function, and wound healing. The natural role of EVs in encapsulating and delivering cargo to modify cellular function highlights the potential to use these particles as therapeutic delivery vehicles. In this chapter, we describe emerging strategies for EV engineering and consider how different approaches to EV production, purification, and design may impact the efficacy of EV-based therapeutics.

KW - Exosome

KW - Extracellular vesicle

KW - Gene delivery

KW - Microvesicle

KW - Nanoparticle

KW - Targeted therapeutics

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AN - SCOPUS:85029009936

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JO - Advances in Genetics

JF - Advances in Genetics

ER -

Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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