Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Mi Ran Choi, Rizia Bardhan, Katie J. Stanton-Maxey, Sunil Badve, Harikrishna Nakshatri, Keith M. Stantz, Ning Cao, Naomi J. Halas, Susan E. Clare

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalCancer Nanotechnology
Volume3
Issue number1-6
DOIs
StatePublished - Dec 2012

Funding

Acknowledgments This work was funded by The Breast Cancer Research Foundation (S.E.C., M.C.); Susan G. Komen for the Cure®, grant number SAC 110004 (S.B.) and grant number SAC110025 (H.N.); the Robert A. Welch Foundation (N.J.H.; C-1220), and The Division of General Surgery, Indiana University School of Medicine (S.E.C.).

Keywords

  • Blood-brain barrier
  • Brain metastasis
  • Breast cancer
  • Gold-silica nanoshell
  • Nanoparticle

ASJC Scopus subject areas

  • Biomedical Engineering
  • Oncology
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry

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