Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients

T. W. Wu, G. A. Levy*, Samuel Yiu, J. X. Au, P. D. Greig, S. M. Strasberg, M. Ettles, M. Abecassis, R. A. Superina, B. Langer, L. M. Blendis, M. J. Phillips, B. R. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

For 51 liver allograft recipients, we evaluated whether serum profiles of delta (Bd) and conjugated bilirubins (Bc) could be used to diagnose rejection during the first 30-50 postoperative days, in comparison with histology as the 'gold standard'. Daily measurements of aspartate aminotransferase, alkaline phosphatase, total bilirubin, Bd, and Bc were made, the last two by liquid chromatography. In 34 patients without any biochemical or histological evidence of rejection, within seven to 10 postoperative days Bd increased to >40-50% of total bilirubin, while Bc decreased to <10%. In patients with severe rejections resulting in death, Bc increased rapidly to >50%, while Bd remained <30%. In 24 histologically proven episodes of rejection in 17 patients there was either a rapid decrease in Bd or its persistence at 30%, plus either a steep increase in Bc, or its remaining at >50% total bilirubin. Treatment of rejection resulted in a prompt reversal of these trends. Individually promising as prognostic adjuncts to existing liver-function markers, Bd and Bc also complemented each other, rendering the diagnosis of liver rejection much more incisive.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalClinical Chemistry
Volume36
Issue number1
StatePublished - Feb 19 1990

Fingerprint

Transplants
Bilirubin
Liver
Histology
Liquid chromatography
Aspartate Aminotransferases
Liquid Chromatography
Allografts
Alkaline Phosphatase
Transplant Recipients
Serum
Therapeutics

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Wu, T. W., Levy, G. A., Yiu, S., Au, J. X., Greig, P. D., Strasberg, S. M., ... Taylor, B. R. (1990). Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients. Clinical Chemistry, 36(1), 9-14.
Wu, T. W. ; Levy, G. A. ; Yiu, Samuel ; Au, J. X. ; Greig, P. D. ; Strasberg, S. M. ; Ettles, M. ; Abecassis, M. ; Superina, R. A. ; Langer, B. ; Blendis, L. M. ; Phillips, M. J. ; Taylor, B. R. / Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients. In: Clinical Chemistry. 1990 ; Vol. 36, No. 1. pp. 9-14.
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abstract = "For 51 liver allograft recipients, we evaluated whether serum profiles of delta (Bd) and conjugated bilirubins (Bc) could be used to diagnose rejection during the first 30-50 postoperative days, in comparison with histology as the 'gold standard'. Daily measurements of aspartate aminotransferase, alkaline phosphatase, total bilirubin, Bd, and Bc were made, the last two by liquid chromatography. In 34 patients without any biochemical or histological evidence of rejection, within seven to 10 postoperative days Bd increased to >40-50{\%} of total bilirubin, while Bc decreased to <10{\%}. In patients with severe rejections resulting in death, Bc increased rapidly to >50{\%}, while Bd remained <30{\%}. In 24 histologically proven episodes of rejection in 17 patients there was either a rapid decrease in Bd or its persistence at 30{\%}, plus either a steep increase in Bc, or its remaining at >50{\%} total bilirubin. Treatment of rejection resulted in a prompt reversal of these trends. Individually promising as prognostic adjuncts to existing liver-function markers, Bd and Bc also complemented each other, rendering the diagnosis of liver rejection much more incisive.",
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Wu, TW, Levy, GA, Yiu, S, Au, JX, Greig, PD, Strasberg, SM, Ettles, M, Abecassis, M, Superina, RA, Langer, B, Blendis, LM, Phillips, MJ & Taylor, BR 1990, 'Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients', Clinical Chemistry, vol. 36, no. 1, pp. 9-14.

Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients. / Wu, T. W.; Levy, G. A.; Yiu, Samuel; Au, J. X.; Greig, P. D.; Strasberg, S. M.; Ettles, M.; Abecassis, M.; Superina, R. A.; Langer, B.; Blendis, L. M.; Phillips, M. J.; Taylor, B. R.

In: Clinical Chemistry, Vol. 36, No. 1, 19.02.1990, p. 9-14.

Research output: Contribution to journalArticle

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T1 - Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients

AU - Wu, T. W.

AU - Levy, G. A.

AU - Yiu, Samuel

AU - Au, J. X.

AU - Greig, P. D.

AU - Strasberg, S. M.

AU - Ettles, M.

AU - Abecassis, M.

AU - Superina, R. A.

AU - Langer, B.

AU - Blendis, L. M.

AU - Phillips, M. J.

AU - Taylor, B. R.

PY - 1990/2/19

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N2 - For 51 liver allograft recipients, we evaluated whether serum profiles of delta (Bd) and conjugated bilirubins (Bc) could be used to diagnose rejection during the first 30-50 postoperative days, in comparison with histology as the 'gold standard'. Daily measurements of aspartate aminotransferase, alkaline phosphatase, total bilirubin, Bd, and Bc were made, the last two by liquid chromatography. In 34 patients without any biochemical or histological evidence of rejection, within seven to 10 postoperative days Bd increased to >40-50% of total bilirubin, while Bc decreased to <10%. In patients with severe rejections resulting in death, Bc increased rapidly to >50%, while Bd remained <30%. In 24 histologically proven episodes of rejection in 17 patients there was either a rapid decrease in Bd or its persistence at 30%, plus either a steep increase in Bc, or its remaining at >50% total bilirubin. Treatment of rejection resulted in a prompt reversal of these trends. Individually promising as prognostic adjuncts to existing liver-function markers, Bd and Bc also complemented each other, rendering the diagnosis of liver rejection much more incisive.

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Wu TW, Levy GA, Yiu S, Au JX, Greig PD, Strasberg SM et al. Delta and conjugated bilirubin as complementary markers of early rejection in liver-transplant recipients. Clinical Chemistry. 1990 Feb 19;36(1):9-14.