Delta and sigma sites of clonal NCB20 cells do not modulate calcium uptake

R. E. West*, S. B. Freedman, G. Dawson, R. J. Miller, M. L. Villereal

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Opiate alkaloids and peptides are reported to inhibit 45Ca2+ binding to synaptic plasma membranes and uptake into brain synaptosomes. We have examined the effects of a number of opiates on 45Ca2+ uptake in a clonal cell line NCB20 which expresses multiple opioid binding sites. The cells express voltage-dependent calcium channels that are blocked by verapamil and nifedipine. In contrast to brain, 45Ca2+ uptake in these cells, in normal or high potassium medium, is unaffected by opiates. This difference may be due to the particular receptor types; the δ and σ sites of these cells do not inhibit 45Ca2+ uptake.

Original languageEnglish (US)
Pages (from-to)1335-1338
Number of pages4
JournalLife Sciences
Volume31
Issue number12-13
DOIs
StatePublished - Sep 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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