Demonstration of substance P immunoreactivity in the nucleus dorsalis of human spinal cord

Erik P. Pioro, J. Trevor Hughes, A. Claudio Cuello*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Substance P immunoreactivity has been detected in varicosities around cell bodies of the nucleus dorsalis (Clarke's column) of the human spinal cord. This immunostaining probably represents neuropeptide immunoreactivity either in the nerve terminals of spinal interneurone, descending projections or in the primary dorsal root afferents which have been shown previously to synapse with the neurones of Clarke's column. The presence of substance P immunoreactivity in the human nucleus dorsalis suggests a role of substance P in the transmission of proprioceptive and exteroceptive information from the lower trunk and limbs to the cerebellum.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalNeuroscience Letters
Volume51
Issue number1
DOIs
StatePublished - Sep 28 1984

Keywords

  • dorsal spinocerebellar tract
  • nucleus dorsalis
  • proproception
  • substance P

ASJC Scopus subject areas

  • General Neuroscience

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