Dendritic Cell Regulation of T Helper Cells

Xiangyun Yin, Shuting Chen, Stephanie C. Eisenbarth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations

Abstract

As the professional antigen-presenting cells of the immune system, dendritic cells (DCs) sense the microenvironment and shape the ensuing adaptive immune response. DCs can induce both immune activation and immune tolerance according to the peripheral cues. Recent work has established that DCs comprise several phenotypically and functionally heterogeneous subsets that differentially regulate T lymphocyte differentiation. This review summarizes both mouse and human DC subset phenotypes, development, diversification, and function. We focus on advances in our understanding of how different DC subsets regulate distinct CD4 bsup + esup T helper (Th) cell differentiation outcomes, including Th1, Th2, Th17, T follicular helper, and T regulatory cells. We review DC subset intrinsic properties, local tissue microenvironments, and other immune cells that together determine Th cell differentiation during homeostasis and inflammation.

Original languageEnglish (US)
Pages (from-to)759-790
Number of pages32
JournalAnnual Review of Immunology
Volume39
DOIs
StatePublished - Apr 26 2021

Keywords

  • dendritic cells
  • Tfh cells
  • Th1 cells
  • Th17 cells
  • Th2 cells
  • Treg cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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