Densitometric and geometric measurement of the proximal femur in elderly women with and without osteoporotic vertebral fractures by volumetric quantitative multi-slice CT

Sheng Yong Wu*, Ji Qi, Ying Lu, Jing Lan, Jin Chao Yu, Lian Qing Wen, Zhuoli Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral neck (NECK) by dual energy X-ray absorptiometry (DXA): osteoporosis with (OP-FX, 53 cases) or without vertebral fracture (OP-NONFX, 94 cases), or normal BMD (CONTROL, 90 cases). Volumetric BMD of trabecular bone (TRAB), integral bone (INTGL) and cortical bone (CORT) with neck axis length (NAL) and minimum cross-section area (mCSA) measures of the left femoral neck were calculated, respectively, by using OsteoCAD software based on MSCT scans of the abdominal-pelvic region of all participants, then the index of femoral neck strength (FNSI) was estimated. The values of TRAB, CORT and INTGL of OP-FX were significantly lower than those of OP-NONFX, with the decrease in 6.8-21.8%, as well as being lower than those in CONTROL, whereas no significant differences in the values of AP-SPINE and NECK were found between OP-FX and OP-NONFX. No significant difference of the value of mCSA was found among these three groups. The NAL value of OP-NONFX was larger than that of CONTROL. FNSI of femoral neck in OP-FX (0.42 ± 0.15 g2/cm4) was significantly lower than OP-NONFX (0.50 ± 0.14 g2/cm4) (p < 0.05). vQCT measurement seemed to be more effective than DXA in evaluating hip densitometric changes and discriminating osteoporotic elderly subjects with fractured vertebrae from the non-fractured in a group of Chinese women.

Original languageEnglish (US)
Pages (from-to)682-689
Number of pages8
JournalJournal of Bone and Mineral Metabolism
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2010

Keywords

  • Bone mineral density (BMD)
  • Elderly women
  • Hip fracture
  • Osteoporosis
  • Volumetric QCT

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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