Dental health status and patient-reported outcomes at baseline in patients participating in the osteonecrosis of the jaw registry study, SWOG S0702

Catherine H. Van Poznak*, Amy Darke, Carol M. Moinpour, Robert A. Bagramian, Mark M. Schubert, Julie R. Gralow, James L. Wade, Joseph M. Unger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: SWOG S0702 was a cohort study of patients with cancer with bone metastases due to any cancer. Using baseline data from S0702, this report characterizes the oral health and oral health-related quality of life (OHRQoL) of patients with advanced cancer. Methods: S0702 case report forms captured dental assessment and patient-reported outcome (PRO) data. This analysis compares PRO dental discomfort with selected clinical assessments of dental health. This analysis focuses on the 2294 patients who underwent baseline dental examination prior to study registration, but also reports on the 1235 patients for whom only OHRQol data are available. Dental characteristics including the number of teeth and the presence of gingivitis and periodontal disease were examined for correlation with PRO of oral pain, interference with eating, smiling, speech, or quality of life. Results: The median age of the study participants was 62. Greater than 60% of the 2294 patients with baseline dental assessments had none to mild plaque, calculus, gingivitis, or periodontal disease, suggesting that most of this cohort had good oral hygiene. However, in each of these same categories, approximately 6% had dental findings classified as severe conditions (poor oral hygiene). There was strong evidence that the presence of periodontal disease, gingivitis, and number of teeth was correlated with lower OHRQoL across multiple domains, including pain (mouth or jaw), interference with eating, smiling and speech, and overall quality of life. Conclusions: This report characterizes the oral health and OHRQoL of patients with advanced bone metastases receiving palliative therapy. Trial registration: ClinicalTrials.gov Identifier: NCT00874211

Original languageEnglish (US)
Pages (from-to)1191-1199
Number of pages9
JournalSupportive Care in Cancer
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Bone metastases
  • Cancer
  • Oral health
  • Patient-reported outcomes

ASJC Scopus subject areas

  • Oncology

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