Dependence of arterial remodeling on locally altered blood pressure

S. Q. Liu*, Y. C. Fung

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Two experimental models were used to study the effect of locally altered blood pressure on the remodeling of the cells and extracellular matrices of the splenic and ileal arteries. In the first model, the abdominal aorta was surgically constricted at a location between the celiac and mesenteric arterial bifurcations, which resulted in a higher increase in the blood pressure at the splenic arteries than that at the ileal arteries. In the second, the aorta was constricted at a location between the mesenteric and renal arterial bifurcations, which resulted in an identical change in the blood pressure in both arteries. The amount of the geometry of the intima, smooth muscle cells, fibroblasts, collagen bundles and elastic laminae of the splenic and ileal arteries were measured at scheduled times by electron microscopy. This model allows the study of arterial remodeling in response to different levels of blood pressure in similar arteries of the same animal and to determine whether the remodeling processes are dependent on the local blood pressure.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages59-60
Number of pages2
Volume29
StatePublished - Jan 1 1995
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period6/28/957/2/95

ASJC Scopus subject areas

  • Engineering(all)

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