Depo-medroxyprogesterone in women on antiretroviral therapy: Effective contraception and lack of clinically significant interactions

S. E. Cohn*, J. G. Park, D. H. Watts, A. Stek, J. Hitti, P. A. Clax, S. Yu, J. J L Lertora

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

We conducted an open-label, steady-state pharmacokinetic (PK) study of drug interactions among HIV-infected women treated with depo-medroxyprogesterone acetate (DMPA) while on nucleoside analogues plus nelfinavir (N = 21), efavirenz (N = 17), or nevirapine (N = 16); or nucleosides only or no antiretroviral therapy as a control group (N = 16). PK parameters were estimated using non-compartmental analysis, with between-group comparisons of medroxyprogesterone acetate (MPA) PKs and within-subject comparisons of ARV PKs before and 4 weeks after DMPA dosing. Plasma progesterone levels were measured at baseline and at 2, 4, 6, 8, 10, and 12 weeks after DMPA dosing. There were no significant changes in MPA area under the concentration curve, peak or trough concentrations, or apparent clearance in the nelfinavir, efavirenz, or nevirapine groups compared to the control group. Minor changes in nelfinavir and nevirapine drug exposure were seen after DMPA, but were not considered clinically significant. Suppression of ovulation was maintained.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalClinical pharmacology and therapeutics
Volume81
Issue number2
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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