David C. Mohr*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Depression is common among people with multiple sclerosis (MS). The 12-month prevalence of major depressive disorder is twice that seen in the general population. This chapter reviews potential explanations for this increased prevalence, including MS pathogenic factors such as inammation; lesion volume in specific frontal, temporal, and/or parietal brain regions; genetic predisposition; and psychosocial factors. This chapter also discusses issues in diagnosis and screening of depression in MS. Finally, trials examining the efficacy of pharmacotherapy and psychotherapy for the treatment of depression in MS are reviewed. After reading this chapter, you will be able to.

Original languageEnglish (US)
Title of host publicationMultiple Sclerosis Rehabilitation
Subtitle of host publicationFrom Impairment to Participation
PublisherCRC Press
Number of pages19
ISBN (Electronic)9781439828854
ISBN (Print)9781138072565
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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