Depression and biomarkers of cardiovascular disease

Allison J. Carroll, Olivia E. Bogucki

Research output: Chapter in Book/Report/Conference proceedingChapter


Over the past several decades, burgeoning research has indicated that depression is a causal risk factor for cardiovascular disease (CVD). While the underlying pathways are multifaceted, there is evidence of a biological basis for this relationship. In this chapter, we review a range of pathophysiological mechanisms through which depression is hypothesized to increase risk for CVD among otherwise healthy adults. Specifically, we assess the evidence supporting associations between depression and various functional, circulating, and structural biomarkers of cardiac health. When possible, we also demonstrate the ways in which these relationships have been linked with CVD outcomes. In addition, we summarize psychosocial factors that likely contribute to or influence this relationship, we identify some of the limitations of studying these biomarkers, and we propose future directions for research in this area.

Original languageEnglish (US)
Title of host publicationThe Neuroscience of Depression, 1st Edition
Subtitle of host publicationVolume 1-2
ISBN (Electronic)9780128180099
ISBN (Print)9780128180105
StatePublished - Jan 1 2021


  • Behavioral medicine
  • Biomarkers
  • Biopsychosocial model
  • Cardiovascular disease
  • Depression
  • Health psychology
  • Risk factor

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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