Abstract
Over the past several decades, burgeoning research has indicated that depression is a causal risk factor for cardiovascular disease (CVD). While the underlying pathways are multifaceted, there is evidence of a biological basis for this relationship. In this chapter, we review a range of pathophysiological mechanisms through which depression is hypothesized to increase risk for CVD among otherwise healthy adults. Specifically, we assess the evidence supporting associations between depression and various functional, circulating, and structural biomarkers of cardiac health. When possible, we also demonstrate the ways in which these relationships have been linked with CVD outcomes. In addition, we summarize psychosocial factors that likely contribute to or influence this relationship, we identify some of the limitations of studying these biomarkers, and we propose future directions for research in this area.
Original language | English (US) |
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Title of host publication | The Neuroscience of Depression, 1st Edition |
Subtitle of host publication | Volume 1-2 |
Publisher | Elsevier |
Pages | V1-239-V1-249 |
Volume | 1-2 |
ISBN (Electronic) | 9780128180099 |
ISBN (Print) | 9780128180105 |
DOIs | |
State | Published - Jan 1 2021 |
Keywords
- Behavioral medicine
- Biomarkers
- Biopsychosocial model
- Cardiovascular disease
- Depression
- Health psychology
- Risk factor
ASJC Scopus subject areas
- General Medicine
- General Neuroscience