Depression, coping and level of neurological impairment in multiple sclerosis

David C. Mohr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


This study examined the relationship between coping and depression in multiple sclerosis patients, and how that relationship varies at different levels of physical impairment. One-hundred and one patients with clinically definite MS were assessed using the Kurtzke Expanded Disability Status Scale (EDSS), the Ways of Coping Inventory (WCI) with three sub-scales developed by Wineman et al, and the Beck Depression Inventory (BDI). Depression was significantly higher at more advanced levels of neurologic impairment than at lower levels. Escape-Avoidance and Emotional Respite were positively related to level of depression. Planful Problem-Solving and Cognitive Reframing were negatively related to depression. An interaction between coping, depression, and level of neurologic impairment was observed in which Planful Problem-Solving and Cognitive Reframing were more strongly related to depression at higher levels of impairment. The interaction effect for Escape-Avoidance and Emotional Respite with depression and level of impairment did not reach significance. It was concluded that there is a significant interaction between level of neurologic impairment, coping behaviors, and depression in patients with MS.

Original languageEnglish (US)
Pages (from-to)254-258
Number of pages5
JournalMultiple Sclerosis
Issue number4
StatePublished - 1997


  • Chronic illness
  • Coping
  • Depression
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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