TY - JOUR
T1 - Depression, parkinsonian symptoms, and negative symptoms in schizophrenics treated with neuroleptics
AU - Prosser, Elisabeth S.
AU - Csernansky, John G.
AU - Kaplan, Jonathan
AU - Thiemann, Sue
AU - Becker, Thomas J.
AU - Hollister, Leo E.
PY - 1987/2
Y1 - 1987/2
N2 - To determine whether depression and neuroleptic-induced parkinsonism confound the clinical assessment of negative symptoms in schizophrenics, we evaluated 45 outpatient schizophrenics for depression, parkinsonian symptoms, and negative symptoms using standard clinical rating scales. Neuroleptic and anticholinergic dose and plasma activity were also determined. Associations between negative symptoms and these clinical and drug variables were examined using a multivariate statistical model. Negative symptoms were significantly correlated with several parkinsonian symptoms, some vegetative features of depression, and with anticholinergic dose. No significant correlations were found between negative symptoms and cognitive features of depression, or neuroleptic and anticholinergic plasma activity. These findings suggest that assessment criteria for negative symptoms, depression, and drug-induced parkinsonism overlap in treated schizophrenics. Strategies for differentiating these clinical syndromes are discussed.
AB - To determine whether depression and neuroleptic-induced parkinsonism confound the clinical assessment of negative symptoms in schizophrenics, we evaluated 45 outpatient schizophrenics for depression, parkinsonian symptoms, and negative symptoms using standard clinical rating scales. Neuroleptic and anticholinergic dose and plasma activity were also determined. Associations between negative symptoms and these clinical and drug variables were examined using a multivariate statistical model. Negative symptoms were significantly correlated with several parkinsonian symptoms, some vegetative features of depression, and with anticholinergic dose. No significant correlations were found between negative symptoms and cognitive features of depression, or neuroleptic and anticholinergic plasma activity. These findings suggest that assessment criteria for negative symptoms, depression, and drug-induced parkinsonism overlap in treated schizophrenics. Strategies for differentiating these clinical syndromes are discussed.
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U2 - 10.1097/00005053-198702000-00006
DO - 10.1097/00005053-198702000-00006
M3 - Article
C2 - 2879880
AN - SCOPUS:0023102501
SN - 0022-3018
VL - 175
SP - 100
EP - 105
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 2
ER -
