Depressive symptoms are not associated with inflammation in younger and older adults in the Philippines

Thomas McDade*, Judith B. Borja, Linda S. Adair, Christopher W Kuzawa

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations


Depression is positively associated with chronic inflammation in industrialized settings with low burdens of infectious disease, but the pattern of association in environments with higher levels of microbial exposure is not known. We measured C-reactive protein (CRP) and interleukin 6 (IL6) in community-based samples of young adults (20-22 years) and older women (35-69 years) in the Philippines. Concentrations of CRP and IL6 were low, and bivariate and multivariate regression analyses indicated no associations between depressive symptoms and inflammation in either sample. Results are interpreted in light of prior research indicating that higher levels of microbial exposure in infancy have lasting effects on the regulation of inflammation, and may prevent the emergence of a relationship between depression and inflammation in adulthood.

Original languageEnglish (US)
Article numbereos004
Pages (from-to)18-23
Number of pages6
JournalEvolution, Medicine, and Public Health
Issue number1
StatePublished - Jan 1 2013


  • Cardiovascular disease
  • Developmental origins of adult disease
  • Human ecological immunology
  • Infectious disease
  • Psychoneuroimmunology

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Health, Toxicology and Mutagenesis

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