Depressive Symptoms in Children with Chronic Kidney Disease

Amy J. Kogon, Matthew B. Matheson, Joseph T. Flynn, Arlene C. Gerson, Bradley A. Warady, Susan L. Furth, Stephen R. Hooper, Allison Dart, Larry Greenbaum, Jens Goebel, Mark Mitsnefes, Craig Wong, Sahar Fathallah, Isidro Salusky, Ora Yadin, Katherine Dell, Bruce Morgenstern, Tom Blydt-Hansen, Cynthia Pan, Keefe DavisAmira Al-Uzri, Randall Jenkins, Anthony Portale, Mouin Seikaly, Martin Turman, Cynthia Wong, Steven Alexander, Colleen Hastings, Nancy Rodig, William Harmon, Sharon Bartosh, Nadine Benador, Robert Mak, Ellen Wood, Gary Lerner, Susan Massengill, Guillermo Hidalgo, Meredith Atkinson, Debbie Gipson, Poyyapakkam Srivaths, Joshua Samuels, Frederick Kaskel, Debora Mattosian, Yi Cai, Sharon Andreoli, Jeffrey Saland, Victoria Norwood, Rulan Parekh, Lisa Robinson, Craig Langman, Chronic Kidney Disease in Children (CKiD) Study Group

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P <.05), and lower HRQoL by parent and child reports (effect estimates, -15.48; 95% CI, -28.71 to -2.24 and -18.39; 95% CI, -27.81 to -8.96, respectively). CDI score was not related to change in glomerular filtration rate. Conclusion Children with depression had lower psychoeducational skills and worse HRQoL. Identifying and treating depression should be evaluated as a means of improving the academic performance and HRQoL of children with chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)164-170.e1
JournalJournal of Pediatrics
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Depressive Symptoms in Children with Chronic Kidney Disease'. Together they form a unique fingerprint.

Cite this