Depth-resolved low-coherent backscattering spectroscopy

Young L. Kim*, Yang Liu, Vladimir Turzhitsky, Ramesh K. Wali, Hemant K. Roy, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

Although the phenomenon of coherent backscattering (CBS) in non-biological media has generated substantial research interest, observing CBS in biological tissue has been extremely difficult. Thus, this phenomenon has awaited its applications in tissue optics over the last two decades. Here we demonstrate depth-resolved spectroscopic elastic-light scattering measurements in tissue by use of low-coherent backscattering (LCBS) spectroscopy. The depth resolution is achieved by exploiting the nature of the LCBS peak that contains information about a wide range of tissue depths. We further demonstrate that the depth-resolved LCBS spectroscopy has the potential for identifying the location of the origin of precancerous transformations in the colon at an early, previously undetectable stage.

Original languageEnglish (US)
Article number51
Pages (from-to)297-307
Number of pages11
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5690
DOIs
StatePublished - Jul 21 2005
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Keywords

  • Backscattering
  • Early cancer detection
  • Elastic light scattering
  • Light scattering spectroscopy
  • Low-coherence illumination

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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