Deregulation of interferon signaling in malignant cells

Efstratios Katsoulidis; Surinder Kaur; Leonidas C. Platanias

doi:10.3390/ph3020406

Deregulation of interferon signaling in malignant cells

Efstratios Katsoulidis, Surinder Kaur, Leonidas C. Platanias

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.

Original language	English (US)
Pages (from-to)	406-418
Number of pages	13
Journal	Pharmaceuticals
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/ph3020406
State	Published - 2010

Keywords

Cancer
Interferon
Signaling pathways

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ph3020406

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title = "Deregulation of interferon signaling in malignant cells",

abstract = "Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.",

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T1 - Deregulation of interferon signaling in malignant cells

AU - Katsoulidis, Efstratios

AU - Kaur, Surinder

AU - Platanias, Leonidas C.

PY - 2010

Y1 - 2010

N2 - Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.

AB - Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.

KW - Cancer

KW - Interferon

KW - Signaling pathways

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DO - 10.3390/ph3020406

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SN - 1424-8247

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SP - 406

EP - 418

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 2

ER -

Deregulation of interferon signaling in malignant cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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