Deregulation of interferon signaling in malignant cells

Efstratios Katsoulidis, Surinder Kaur, Leonidas C. Platanias

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.

Original languageEnglish (US)
Pages (from-to)406-418
Number of pages13
JournalPharmaceuticals
Volume3
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Cancer
  • Interferon
  • Signaling pathways

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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